The role of testosterone in trichloroethylene penetration in vitro
- Univ. of Medicine and Dentistry of New Jersey, Newark (United States)
Sex differences are known to exist in the metabolism and bioavailability of trichloroethylene (TCE). This study revealed that dermal penetration of ({sup 14}C)TCE in vitro was twofold greater in untreated female than in untreated male Sprague-Dawley rats. Since testosterone has been shown to mediate a wide variety of sex differences, its role in dermal penetration of ({sup 14}C)TCE was investigated. Penetration was measured by using an in vitro evaporation-penetration cell with a 10-hour collection period. Depriving male rats of testosterone (by castration) resulted in increased values for total penetration, area under the curve (AUC), and penetration slopes compared to those found in the female control group. Administration of testosterone to female animals produced values for total penetration, AUC, and penetration slopes significantly lower than those of the female control group.
- OSTI ID:
- 5740108
- Journal Information:
- Environmental Research; (United States), Vol. 54:1; ISSN 0013-9351
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CHLORINATED ALIPHATIC HYDROCARBONS
BIOLOGICAL AVAILABILITY
TESTOSTERONE
BIOCHEMICAL REACTION KINETICS
CARBON 14 COMPOUNDS
IN VITRO
METABOLISM
RATS
SEX DEPENDENCE
SKIN ABSORPTION
TRACER TECHNIQUES
ABSORPTION
ANDROGENS
ANDROSTANES
ANIMALS
CARBON COMPOUNDS
HALOGENATED ALIPHATIC HYDROCARBONS
HORMONES
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KETONES
KINETICS
LABELLED COMPOUNDS
MAMMALS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
REACTION KINETICS
RODENTS
STEROID HORMONES
STEROIDS
UPTAKE
VERTEBRATES
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