Assessment of sup 18 F gaseous releases during the production of sup 18 F-fluorodeoxyglucose

Journal Article · Wed May 01 00:00:00 EDT 1991 · Health Physics; (USA)

DOI:https://doi.org/10.1097/00004032-199105000-00003· OSTI ID:5735495

Kleck, J H; Benedict, S H; Cook, J S; Birdsall, R L; Satyamurthy, N ^[1]

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1. Univ. of California, Los Angeles (USA)

Fluorodeoxyglucose labeled with {sup 18}F ({sup 18}F-FDG) is the most commonly used radiopharmaceutical in positron emission tomography (PET). Fluorine-18-labeled FDG is used as a diagnostic tool in PET studies to monitor the physiology of the brain, diagnose heart function and disease, and to image cancerous tumors. At the University of California, Los Angeles (UCLA), three cyclotrons produce ({sup 18}F)-fluoride ion using {sup 18}O-enriched water targets. Fluorine-18, which has a half-life of 109.8 min, is produced using an {sup 18}O(p.n.){sup 18}F reaction and is chemically processed to yield {sup 18}F-FDG. This study presents data which demonstrate that during the radiochemical processes involved in the production of {sup 18}F-FDG, gaseous effluent containing {sup 18}F is released. Forty cyclotron production runs with average end of cyclotron bombardment activities of 15.9 +/- 1.88 GBq (430 +/- 50.8 mCi) and end of radiochemical synthesis activities of 5.40 +/- 1.27 GBq (146 +/- 34.3 mCi) yield {sup 18}F gaseous effluent releases ranging from 0 to 2560 MBq (0 to 69.2 mCi) with a mean of 437 MBq (11.8 mCi). Temporal correlation of the {sup 18}F gaseous releases during {sup 18}F-FDG radiochemical production has tied the {sup 18}F release to the addition of the glucose precursor (mannotriflate) and ethyl ether in the radiochemical processing. The results are presented in terms of activities released and dilution factors required from the release stack point to maintain controlled (occupational) and uncontrolled (public) area limits in accordance with the recommendations of the International Commission on Radiological Protection and the regulatory requirements of the federal government.

• OSTI ID: 5735495
• Journal Information: Health Physics; (USA), Vol. 60:5; ISSN 0017-9078
• Country of Publication: United States
• Language: English

Related Subjects

54 ENVIRONMENTAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
FLUORINE 18
MAXIMUM PERMISSIBLE LEVEL
RADIOPHARMACEUTICALS
CHEMICAL PREPARATION
CYCLOTRONS
ENVIRONMENTAL EXPOSURE
OCCUPATIONAL EXPOSURE
OXYGEN 18
POSITRON COMPUTED TOMOGRAPHY
ACCELERATORS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
COMPUTERIZED TOMOGRAPHY
CYCLIC ACCELERATORS
DIAGNOSTIC TECHNIQUES
DRUGS
EMISSION COMPUTED TOMOGRAPHY
EVEN-EVEN NUCLEI
FLUORINE ISOTOPES
HOURS LIVING RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
NANOSEC LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
OXYGEN ISOTOPES
RADIOISOTOPES
SAFETY STANDARDS
STABLE ISOTOPES
STANDARDS
SYNTHESIS
TOMOGRAPHY
540130* - Environment
Atmospheric- Radioactive Materials Monitoring & Transport- (1990-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics