Age differences in intercorrelations between regional cerebral metabolic rates for glucose

Journal Article · Wed Jan 01 00:00:00 EST 1986 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410190111· OSTI ID:5734444

Horwitz, B; Duara, R; Rapoport, S I

Patterns of cerebral metabolic intercorrelations were compared in the resting state in 15 healthy young men (ages 20 to 32 years) and 15 healthy elderly men (ages 64 to 83 years). Controlling for whole-brain glucose metabolism, partial correlation coefficients were determined between pairs of regional cerebral metabolic rates for glucose determined by positron emission tomography using (18F)fluorodeoxyglucose and obtained in 59 brain regions. Compared with the young men, the elderly men had fewer statistically significant correlations, with the most notable reductions observed between the parietal lobe regions, and between the parietal and frontal lobe regions. These results suggest that cerebral functional interactions are reduced in healthy elderly men.

• Research Organization: National Institute on Aging, Bethesda, MD
• OSTI ID: 5734444
• Journal Information: Ann. Neurol.; (United States), Vol. 1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
EMISSION COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
AGE DEPENDENCE
AGING
FLUORINE 18
LABELLED COMPOUNDS
MEN
STATISTICS
TISSUE DISTRIBUTION
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MALES
MAMMALS
MAN
MATHEMATICS
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PRIMATES
RADIOISOTOPES
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
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