Effects of moderate-intensity light on vitamin A-deficient rat retinas
The effects of moderate-intensity light (150 to 200 ft-cd) on retinal structure were compared between retinol-adequate and retinol-deficient rats after 1 to 6 days of light exposure during the 12 hr light phase of the cycle. Both damage to the outer segments and loss of photoreceptor cells were accelerated in retinol-adequate rats. Outer segments in retinas of retinol-adequate rats showed an abnormal staining pattern and disruption of disc structure in the distal portion about 2 days before those of retinol-deficient rats. After 4 days of exposure 24% of the photoreceptor cells had degenerated in the retinol-adequate retinas, but only 6% in the retinol-deficient retinas. By 6 days 65% and 41% of the photoreceptors had degenerated in the retinol-adequate and retinol-deficient retinas, respectively. Thus light exposure induced more rapid degeneration of photoreceptor cells in rats receiving adequate retinol than in those deficient in this vitamin.
- OSTI ID:
- 5733670
- Journal Information:
- Invest. Ophthalmol. Visual Sci.; (United States), Vol. 20:5
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
RETINA
PHOTOSENSITIVITY
VITAMIN A
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
CYTOLOGICAL TECHNIQUES
NUTRITIONAL DEFICIENCY
RATS
VISIBLE RADIATION
ANIMALS
BODY
BODY AREAS
ELECTROMAGNETIC RADIATION
EYES
FACE
HEAD
MAMMALS
ORGANS
RADIATION EFFECTS
RADIATIONS
RODENTS
SENSE ORGANS
SENSITIVITY
VERTEBRATES
VITAMINS
560100* - Biomedical Sciences
Applied Studies- Radiation Effects