Effect of whole brain radiation on local cerebral glucose utilization in the rat

Journal Article · Mon Apr 01 00:00:00 EST 1991 · Neurosurgery; (USA)

DOI:https://doi.org/10.1097/00006123-199104000-00001· OSTI ID:5733171

d'Avella, D; Cicciarello, R; Albiero, F; Mesiti, M; Gagliardi, M E; Russi, E; d'Aquino, A; Princi, P; d'Aquino, S ^[1]

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1. Univ. of Messina, (Italy)

We assessed, by means of the ({sup 14}C)-2-deoxy-D-glucose autoradiography method, the effect of whole-brain x-radiation on local cerebral glucose utilization in the rat brain. Animals were exposed to conventional fractionation (200 +/- 4 cGy/day, 5 days/week; total dose, 4000 cGy). Metabolic experiments were made 2 to 3 weeks after completion of the radiation exposure. In comparison with control and sham-irradiated animals, cerebral metabolic activity was diffusely decreased after irradiation. Statistically significant decreases in metabolic activity were observed in 13 of 27 brain regions studied. In general, the brain areas with the highest basal metabolic rates showed the greatest percentage of decrease in glucose utilization. The concept that radiation suppresses glucose utilization before any morphological change takes place in the cell structures was the basis of this study. Metabolic alterations after irradiation may explain the syndrome of early delayed deterioration observed in humans after whole-brain radiotherapy. These studies have applications to observations made with the ({sup 18}F)-fluorodeoxyglucose method in conjunction with positron emission tomographic scans in patients receiving radiation therapy for intracranial malignancies. The data reported here also have potential clinical implications for the evaluation of a risk/benefit ratio for radiotherapy in patients with benign neurosurgical diseases or children undergoing prophylactic treatment of the central nervous system.

• OSTI ID: 5733171
• Journal Information: Neurosurgery; (USA), Vol. 28:4; ISSN 0148-396X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
BIOLOGICAL RADIATION EFFECTS
GLUCOSE
METABOLISM
AUTORADIOGRAPHY
CARBON 14 COMPOUNDS
FLUORINE 18
POSITRON COMPUTED TOMOGRAPHY
RADIATION DOSES
RATS
TRACER TECHNIQUES
X RADIATION
ALDEHYDES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CARBON COMPOUNDS
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DOSES
ELECTROMAGNETIC RADIATION
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LIGHT NUCLEI
MAMMALS
MONOSACCHARIDES
NANOSEC LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RODENTS
SACCHARIDES
TOMOGRAPHY
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
550501 - Metabolism- Tracer Techniques
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