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Title: Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment

Abstract

Twenty patients with intractable rheumatoid arthritis were treated with 750-rad or 2,000-rad lymphoid irradiation in a randomized double-blind comparative study. Over a 12-month followup period, there was a significant improvement in 4 of 7 and 6 of 7 standard parameters of disease activity following treatment with 750 rads and 2,000 rads, respectively. Transient, short-term toxicity was less frequent with the lower dose. In both groups, there was a sustained peripheral blood lymphopenia, a selective depletion of T helper (Leu-3a+) lymphocytes, and reduced in vitro mitogen responses. These changes did not occur, however, in synovial fluid. These results suggest that 750-rad lymphoid irradiation is as effective as, but less toxic than, that with 2,000 rads in the management of patients with intractable rheumatoid arthritis.

Authors:
; ; ; ; ; ; ; ;
Publication Date:
Research Org.:
St. Vincent's Hospital, Dublin, Ireland
OSTI Identifier:
5730767
Resource Type:
Journal Article
Journal Name:
Arthritis Rheum.; (United States)
Additional Journal Information:
Journal Volume: 1
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 62 RADIOLOGY AND NUCLEAR MEDICINE; RHEUMATIC DISEASES; RADIOTHERAPY; DOSE-RESPONSE RELATIONSHIPS; LYMPHATIC SYSTEM; LYMPHOCYTES; PATIENTS; SIDE EFFECTS; ANIMAL CELLS; BIOLOGICAL MATERIALS; BLOOD; BLOOD CELLS; BODY FLUIDS; CONNECTIVE TISSUE CELLS; DISEASES; LEUKOCYTES; MATERIALS; MEDICINE; NUCLEAR MEDICINE; RADIOLOGY; SKELETAL DISEASES; SOMATIC CELLS; THERAPY; 560151* - Radiation Effects on Animals- Man; 550603 - Medicine- External Radiation in Therapy- (1980-)

Citation Formats

Hanly, J G, Hassan, J, Moriarty, M, Barry, C, Molony, J, Casey, E, Whelan, A, Feighery, C, and Bresnihan, B. Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment. United States: N. p., 1986. Web. doi:10.1002/art.1780290103.
Hanly, J G, Hassan, J, Moriarty, M, Barry, C, Molony, J, Casey, E, Whelan, A, Feighery, C, & Bresnihan, B. Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment. United States. https://doi.org/10.1002/art.1780290103
Hanly, J G, Hassan, J, Moriarty, M, Barry, C, Molony, J, Casey, E, Whelan, A, Feighery, C, and Bresnihan, B. 1986. "Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment". United States. https://doi.org/10.1002/art.1780290103.
@article{osti_5730767,
title = {Lymphoid irradiation in intractable rheumatoid arthritis. A double-blind, randomized study comparing 750-rad treatment with 2,000-rad treatment},
author = {Hanly, J G and Hassan, J and Moriarty, M and Barry, C and Molony, J and Casey, E and Whelan, A and Feighery, C and Bresnihan, B},
abstractNote = {Twenty patients with intractable rheumatoid arthritis were treated with 750-rad or 2,000-rad lymphoid irradiation in a randomized double-blind comparative study. Over a 12-month followup period, there was a significant improvement in 4 of 7 and 6 of 7 standard parameters of disease activity following treatment with 750 rads and 2,000 rads, respectively. Transient, short-term toxicity was less frequent with the lower dose. In both groups, there was a sustained peripheral blood lymphopenia, a selective depletion of T helper (Leu-3a+) lymphocytes, and reduced in vitro mitogen responses. These changes did not occur, however, in synovial fluid. These results suggest that 750-rad lymphoid irradiation is as effective as, but less toxic than, that with 2,000 rads in the management of patients with intractable rheumatoid arthritis.},
doi = {10.1002/art.1780290103},
url = {https://www.osti.gov/biblio/5730767}, journal = {Arthritis Rheum.; (United States)},
number = ,
volume = 1,
place = {United States},
year = {Wed Jan 01 00:00:00 EST 1986},
month = {Wed Jan 01 00:00:00 EST 1986}
}