Positron emission tomographic measurement of cerebral blood flow and permeability-surface area product of water using (/sup 15/O)water and (/sup 11/C)butanol

Journal Article · Thu Oct 01 00:00:00 EDT 1987 · J. Cereb. Blood Flow Metab.; (United States)

DOI:https://doi.org/10.1038/jcbfm.1987.102· OSTI ID:5725557

Herscovitch, P; Raichle, M E; Kilbourn, M R; Welch, M J

We have previously adapted Kety's tissue autoradiographic method for measuring regional CBF in laboratory animals to the measurement of CBF in humans with positron emission tomography (PET) and H/sub 2/(/sup 15/)O. Because this model assumes diffusion equilibrium between tissue and venous blood, the use of a diffusion-limited tracer, such as H/sub 2/(/sup 15/)O, may lead to an underestimation of CBF. We therefore validated the use of (/sup 11/C)butanol as an alternative freely diffusible tracer for PET. We then used it in humans to determine the underestimation of CBF that occurs with H/sub 2/(/sup 15/)O, and thereby were able to calculate the extraction Ew and permeability-surface area product PSw of H/sub 2/(/sup 15/)O. Measurements of the permeability of rhesus monkey brain to (/sup 11/C)butanol, obtained by means of an intracarotid injection, external detection technique, demonstrated that this tracer is freely diffusible up to a CBF of at least 170 ml/min-100 g. CBF measured in baboons with the PET autoradiographic method and (/sup 11/C)butanol was then compared with CBF measured in the same animals with a standard residue detection method. An excellent correspondence was obtained between both of these measurements. Finally, paired PET measurements of CBF were made with both H/sub 2/(/sup 15/)O and (/sup 11/C)butanol in 17 normal human subjects. Average global CBF was significantly greater when measured with (/sup 11/C)butanol (53.1 ml/min-100 g) than with H/sub 2/(/sup 15/)O (44.4 ml/min-100 g). Average global Ew was 0.84 and global PSw was 104 ml/min-100 g. Regional measurements showed a linear relationship between local PSw and CBF, while Ew was relatively uniform throughout the brain. Simulations were used to determine the potential error associated with the use of an incorrect value for the brain-blood partition coefficient for (/sup 11/C)butanol and to calculate the effect of tissue heterogeneity and errors in flow measurement on the calculation of PSw.

• Research Organization: Washington Univ., St. Louis, MO (United States). School of Medicine
• OSTI ID: 5725557
• Journal Information: J. Cereb. Blood Flow Metab.; (United States), Vol. 7:5
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
BLOOD FLOW
POSITRON COMPUTED TOMOGRAPHY
BABOONS
BLOOD-BRAIN BARRIER
BUTANOLS
CARBON 11
COMPARATIVE EVALUATIONS
ERRORS
MAN
MONKEYS
OXYGEN 15
PERMEABILITY
SURFACE AREA
WATER
ALCOHOLS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CARBON ISOTOPES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
HYDROGEN COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPES
LIGHT NUCLEI
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
OXYGEN ISOTOPES
PRIMATES
RADIOISOTOPES
SURFACE PROPERTIES
TOMOGRAPHY
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics