Total lymphoid irradiation in alloimmunity and autoimmunity

Journal Article · Tue Dec 01 00:00:00 EST 1987 · J. Pediatr.; (United States)

DOI:https://doi.org/10.1016/S0022-3476(87)80055-0· OSTI ID:5719825

Strober, S

Total lymphoid irradiation has been used as an immunosuppressive regimen in autoimmune disease and organ transplantation. The rationale for its use originated from studies of patients with Hodgkin disease, in whom this radiotherapy regimen was noted to induce profound and long-lasting immune suppression and yet was well tolerated, with few long-term side effects. Total lymphoid irradiation is a unique immunosuppressive regimen that produces a selective (and long-lasting) reduction in the number and function of helper T cells and certain subsets of B cells. Conventional immunosuppressive drugs show little selectivity, and their effects are short-lived. The most important aspect of total lymphoid irradiation is the potential for achieving transplantation tolerance and permanent remissions in autoimmune disease in laboratory animals. Attempts are being made to achieve similar goals in humans given total lymphoid irradiation, so that immunosuppressive drugs can be ultimately withdrawn from transplant recipients and patients with lupus nephritis. 28 references.

• Research Organization: Stanford Univ. Medical Center, Palo Alto, CA
• OSTI ID: 5719825
• Journal Information: J. Pediatr.; (United States), Vol. 111
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
IMMUNITY
RADIOINDUCTION
LYMPHATIC SYSTEM
BIOLOGICAL RADIATION EFFECTS
DOGS
IMMUNOSUPPRESSION
LYMPHOCYTES
MICE
TRANSPLANTS
ANIMAL CELLS
ANIMALS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
LEUKOCYTES
MAMMALS
MATERIALS
RADIATION EFFECTS
RODENTS
SOMATIC CELLS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals