QSAR analysis and data extrapolation among mammals in a series of aliphatic alcohols

Journal Article · Sun Sep 01 00:00:00 EDT 1985 · Environ. Health Perspect.; (United States)

DOI:https://doi.org/10.2307/3430082· OSTI ID:5718565

Tichy, M; Trcka, V; Roth, Z; Krivucova, M

Concepts of QSAR analysis and biological similarity models are combined for use in extrapolation of LD/sub 50/ values after IP application of a series of aliphatic alcohols (C/sub 1/-C/sub 5/) to mouse, hamster, rat, and guinea pig and rabbit. It has been found that although close correlation exists between LD/sub 50/ values after IP and IV applications for mouse and rat, the QSAR obtained with LD/sub 50/ after IV application are not suitable for a prediction of LD/sub 50/ values after IP application for rabbit. Different transformation or distribution processes in mouse, rat, and rabbit after the two types of applications might be the reason. The LD/sub 50/ values (expressed in mmole/m/sup 2/ of body surface) seem to be independent of mammalian species used (at least within the mouse, rat, hamster, and probably guinea pig series). This fact makes it possible to predict reasonable values of LD/sub 50/ after IP application for rabbit. Expression of toxicity in mmole/m/sup 2/ of body surface may be used in toxicological studies. 24 references, 2 figures, 8 tables.

• Research Organization: Institute of Hygiene and Epidemiology, Praha, Czechoslovakia
• OSTI ID: 5718565
• Journal Information: Environ. Health Perspect.; (United States), Vol. 61
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ALCOHOLS
STRUCTURE-ACTIVITY RELATIONSHIPS
LETHAL DOSES
EXTRAPOLATION
FORECASTING
MAMMALS
BIOLOGICAL MODELS
GUINEA PIGS
HAMSTERS
INTRAPERITONEAL INJECTION
INTRAVENOUS INJECTION
MICE
RABBITS
RATS
SURFACE AREA
TISSUE DISTRIBUTION
WEIGHT
ANIMALS
DISTRIBUTION
DOSES
HYDROXY COMPOUNDS
INJECTION
INTAKE
NUMERICAL SOLUTION
ORGANIC COMPOUNDS
RODENTS
SURFACE PROPERTIES
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)