Lead poisoning and brain cell function
- Johns Hopkins School of Medicine, Baltimore, MD (USA) Kennedy Institute, Baltimore, MD (USA)
Exposure to excessive amounts of inorganic lead during the toddler years may produce lasting adverse effects upon brain function. Maximal ingestion of lead occurs at an age when major changes are occurring in the density of brain synaptic connections. The developmental reorganization of synapses is, in part, mediated by protein kinases, and these enzymes are particularly sensitive to stimulation by lead. By inappropriately activating specific protein kinases, lead poisoning may disrupt the development of neural networks without producing overt pathological alterations. The blood-brain barrier is another potential vulnerable site for the neurotoxic action of lead. protein kinases appear to regulate the development of brain capillaries and the expression of the blood-brain barrier properties. Stimulation of protein kinase by lead may disrupt barrier development and alter the precise regulation of the neuronal environment that is required for normal brain function. Together, these findings suggest that the sensitivity of protein kinases to lead may in part underlie the brain dysfunction observed in children poisoned by this toxicant.
- OSTI ID:
- 5718252
- Journal Information:
- Environmental Health Perspectives; (USA), Vol. 89; ISSN 0091-6765
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
ENZYME ACTIVITY
LEAD COMPOUNDS
BIOLOGICAL EFFECTS
BLOOD-BRAIN BARRIER
NERVE CELLS
ONTOGENESIS
PHOSPHOTRANSFERASES
ANIMAL CELLS
BODY
CENTRAL NERVOUS SYSTEM
ENZYMES
NERVOUS SYSTEM
ORGANS
PHOSPHORUS-GROUP TRANSFERASES
SOMATIC CELLS
TRANSFERASES
560300* - Chemicals Metabolism & Toxicology