Alterations in gastric mucus secretion in rhesus monkeys after exposure to ionizing radiation
The aim of the present study was to evaluate the effect of gamma-irradiation on soluble gastric mucus. Six conscious chair-adapted rhesus monkeys were studied once before and twice after exposure to ionizing irradiation (800 rads). Using a marker (/sup 99m/Tc-DTPA) dilution technique, acidic glycoprotein (AG), neutral glycoprotein (NG), ion, and fluid output were determined during a basal period and after the administration of an 80-ml water load. Irradiation significantly increased the outputs of both AG and NG during the basal period. After the water load, NG output remained elevated but irradiation abolished postload AG output thus inhibiting the normal rise in AG output stimulated by the load. Two days after irradiation NG output had returned to control levels whereas AG output was still suppressed. Sodium and potassium ion outputs were unaltered by irradiation. Chloride and fluid outputs were significantly inhibited on the day of irradiation but had returned to control levels within 3 days. These results indicate that irradiation produces significant changes in both the quantity and nature of the soluble mucus glycoproteins secreted into the gastric juice. It is suggested that these changes may compromise the protective ability of gastric mucus.
- Research Organization:
- Uniformed Services Univ. of the Health Sciences, Bethesda, MD
- OSTI ID:
- 5707483
- Journal Information:
- Gastroenterology; (United States), Vol. 88:3
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
GLUCOPROTEINS
BIOLOGICAL RADIATION EFFECTS
CATIONS
CHLORIDES
DTPA
GAMMA RADIATION
GASTRIC ACID
ISOMERIC NUCLEI
ISOTOPE DILUTION
LABELLED COMPOUNDS
MONKEYS
POTASSIUM COMPOUNDS
SODIUM COMPOUNDS
SOLVENT PROPERTIES
TECHNETIUM 99
TRACER TECHNIQUES
WATER
ALKALI METAL COMPOUNDS
AMINO ACIDS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BODY FLUIDS
CARBOHYDRATES
CARBOXYLIC ACIDS
CHARGED PARTICLES
CHELATING AGENTS
CHLORINE COMPOUNDS
DRUGS
ELECTROMAGNETIC RADIATION
HALIDES
HALOGEN COMPOUNDS
HOURS LIVING RADIOISOTOPES
HYDROGEN COMPOUNDS
INTERMEDIATE MASS NUCLEI
IONIZING RADIATIONS
IONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
MATERIALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
OXYGEN COMPOUNDS
PRIMATES
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
RADIOPROTECTIVE SUBSTANCES
SACCHARIDES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals