Effect of vitamin D3, other drugs altering serum calcium or phosphorus concentrations, and desoxycorticosterone on the distribution of Tc-99m pyrophosphate between target and nontarget tissues
Radioactive imaging agents are chemically designed for selective distribution. Another approach to selectivity is to find stable compounds that favorably influence this distribution. Using a rat model of myocardial necrosis, we studied effects of various stable compounds (as a single, large dose or fractionated into short series) on the ratio, uptake of Tc-99m pyrophosphate (PPi) by the target lesion/uptake by the principal nontarget, bone (L/B). Vitamin D3s ability to increase L/B was mediated by the hypercalcemia and hyperphosphatemia that it caused. The hypercalcemia was accompanied by increased (Ca) in the lesion. In contrast, pulse doses of desoxycorticosterone acetate (DOCA) at 7 and 6 hr before killing increased uptake by lesion, increasing L/B from 0.19 +/- 0.03 to 0.45 +/- 0.08 (p less than 0.01), with no change in serum (Ca) and minimal changes in serum (P), (Na), and (K). DOCA also increased the lesion-to-blood ratio from 6.5 +/- 0.07 to 15.4 +/- 3.9 (p less than 0.05). These results encourage further study of DOCA's effect and investigation of other stable drugs that may influence distribution of other imaging agents.
- OSTI ID:
- 5706799
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 22:6
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MYOCARDIUM
SCINTISCANNING
NECROSIS
DIAGNOSIS
SKELETON
TECHNETIUM 99
TISSUE DISTRIBUTION
BIOLOGICAL LOCALIZATION
CALCIUM
CORTICOSTERONE
IMAGES
ISOMERIC NUCLEI
PHOSPHORUS
PYROPHOSPHATES
UPTAKE
VITAMIN D
ADRENAL HORMONES
ALKALINE EARTH METALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CARDIOVASCULAR SYSTEM
CORTICOSTEROIDS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
ELEMENTS
GLUCOCORTICOIDS
HEART
HORMONES
HOURS LIVING RADIOISOTOPES
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
KETONES
METALS
MUSCLES
NONMETALS
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
PATHOLOGICAL CHANGES
PHOSPHORUS COMPOUNDS
PREGNANES
RADIOISOTOPE SCANNING
RADIOISOTOPES
STEROID HORMONES
STEROIDS
TECHNETIUM ISOTOPES
VITAMINS
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)