Radiation therapy in and about the retina, optic nerve, and anterior visual pathway: psychophysical assessment
Visual changes may develop in patients receiving radiation therapy for malignant neoplasms in and about the optic nerve and anterior visual pathway. Cases have been studied using a series of psychophysical tests, including kinetic perimetry, increment threshold determinations, Flashing Repeat Static Test, and sustained- and transient-like functions. A characteristic time-dependent reduction in sensitivity has been identified in these patients. This finding, in addition to the presence of nerve fiber bundle defects, appears to place the pathologic changes in the axon of the ganglion cell posterior to the lamina cribrosa. Any change in the sustained- and transient-like functions, the organization of which appears to be in the neural retina, was seen only if a concomitant radiation retinopathy was identified.
- Research Organization:
- Univ. of Florida, Gainesville
- OSTI ID:
- 5706426
- Journal Information:
- Arch. Ophthalmol. (Chicago); (United States), Vol. 99:4
- Country of Publication:
- United States
- Language:
- English
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62 RADIOLOGY AND NUCLEAR MEDICINE
NERVES
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
RETINA
LOCAL IRRADIATION
NEOPLASMS
PATIENTS
VISION
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DISEASES
EYES
FACE
HEAD
IRRADIATION
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
SENSE ORGANS
THERAPY
560152* - Radiation Effects on Animals- Animals
550603 - Medicine- External Radiation in Therapy- (1980-)