Low dose neutron late effects: Cataractogenesis

Technical Report · Mon Apr 01 00:00:00 EST 1991

OSTI ID:5704074

Worgul, B V

The work is formulated to resolve the uncertainty regarding the relative biological effectiveness. The endpoint which is being utilized is cataractogenesis. The advantages conferred by this system stems primarily from the non-invasive longitudinal analysis which it allows. It also exploits a well defined system and one which has demonstrated sensitivity to the inverse dose rate effect observed with heavy ions. Four week old rats were divided into 8 dose groups which received single or fractionated total doses of .2, 1.0, 5.0 and 25 cGy of monoenergetic 435 keV neutrons. Special restraining jigs were devised to insure that the eye at the midpoint of the lens received the appropriate energy and dose with a relative error of {plus minus} 5%. The fractionated regimen consisted of four exposures, each administered at 3 hour intervals. The reference radiations, 250 kVp X-rays, were administered in the same fashion but in doses ranging from .5 to 6.0 Gy. The animals are examined on a bi-weekly basis utilizing conventional slit-lamp biomicroscopy and the Scheimpflug Slit-lamp Imaging System. The follow-ups will continue throughout the lifespan of the animals. When opacification begins full documentation will involve the Zeiss imaging system and Oxford retroillumination photography. The processing routinely employs the Merriam/Focht scoring system for cross-referencing with previous cataract studies and establish cataractogenecity using a proven scoring method.

• Research Organization: Columbia Univ., New York, NY (USA)
• Sponsoring Organization: USDOE; USDOE, Washington, DC (USA)
• DOE Contract Number: FG02-90ER61009
• OSTI ID: 5704074
• Report Number(s): DOE/ER/61009-1; ON: DE91011020; TRN: 91-014296
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CATARACTS
RADIOINDUCTION
EYES
BIOLOGICAL RADIATION EFFECTS
NEUTRONS
RBE
ACUTE IRRADIATION
FRACTIONATED IRRADIATION
PROGRESS REPORT
RADIATION DOSES
RATS
ACUTE EXPOSURE
ANIMALS
BARYONS
BIOLOGICAL EFFECTS
BODY
BODY AREAS
DISEASES
DOCUMENT TYPES
DOSES
ELEMENTARY PARTICLES
FACE
FERMIONS
HADRONS
HEAD
IRRADIATION
MAMMALS
NUCLEONS
ORGANS
RADIATION EFFECTS
RODENTS
SENSE ORGANS
SENSE ORGANS DISEASES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals