Differential presynaptic effects of hexachlorocyclohexane isomers on noradrenaline release in cerebral cortex

Journal Article · Tue Jan 01 00:00:00 EST 1991 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(91)90599-7· OSTI ID:5698744

Cristofol, R M; Rodriguez-Farre, E ^[1]

---

1. Consejo Superior de Investigaciones Cientificas, Barcelona (Spain)

To investigate presynaptic effects of hexachlorocyclohexane (HCH) isomers, the release of noradrenaline (NA) in brain tissue was analyzed using rat cerebral cortical slices preloaded with ({sup 3}H)-NA. {gamma}-HCH (lindane) 50 {mu}M significantly enhanced the ({sup 3}H)-NA release evoked by 15-25 mM K{sup +}. {alpha}- and {beta}-HCH did not produce any significant effect on K{sup +}-evoked ({sup 3}H)-NA release. {delta}-HCH induced a significant decrease of the 25 mM K{sup +}-evoked release of ({sup 3}H)-NA. The effect of the {gamma}- and {delta}-HCH isomers on the presynaptic action of the {alpha}{sub 2}-agonist clonidine and the {alpha}{sub 2}-antagonist yohimbine was also studied. The presynaptic inhibitory effect of clonidine and the stimulatory effect of yohimbine on ({sup 3}H)-NA release was attenuated by lindane and {delta}-HCH, respectively. These results are consistent with a presynaptic action of the HCH isomers on noradrenergic release processes.

• OSTI ID: 5698744
• Journal Information: Life Sciences; (United States), Vol. 49:15; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
LINDANE
BIOLOGICAL EFFECTS
NORADRENALINE
SECRETION
CEREBRAL CORTEX
ISOMERS
RATS
TRACER TECHNIQUES
TRITIUM COMPOUNDS
ADRENAL HORMONES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CEREBRUM
CHLORINATED ALICYCLIC HYDROCARBONS
DRUGS
HALOGENATED ALICYCLIC HYDROCARBONS
HORMONES
HYDROGEN COMPOUNDS
INSECTICIDES
ISOTOPE APPLICATIONS
MAMMALS
NERVOUS SYSTEM
NEUROREGULATORS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
PESTICIDES
RODENTS
SYMPATHOMIMETICS
VERTEBRATES
550501* - Metabolism- Tracer Techniques