Lead acetate delays rapid postnatal mouse brain and body growth
- Brandeis Univ., Waltham, MA (United States)
Starting at parturition and continuing until weaning, mothers of five mouse litters received tap water while five others had 10 mg PbAc/ml in their drinking water. The offspring receiving lead from the mothers had significantly lower body weights after the first days of receiving lead; their slowed body growth led to a 2-day delay of onset of their last rapid body growth stage. They also had significantly smaller brain weights between age 14 days and weaning. The onset of rapid brain growth was delayed from its usual onset at 16-18 days to about 22-23 days before rising to about the same value as the control mice at 26 days. Thus, the initial effect on brain growth is decidedly greater than on body growth, though brain weight later reaches close to the control value.
- OSTI ID:
- 5696147
- Journal Information:
- Life Sciences; (United States), Vol. 49:16; ISSN 0024-3205
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ANIMAL GROWTH
INHIBITION
LEAD
TERATOGENESIS
BRAIN
MICE
PRENATAL EXPOSURE
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
ELEMENTS
GROWTH
MAMMALS
METALS
NERVOUS SYSTEM
ORGANS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology