Study of gastrointestinal opiate receptors: the role of the mu receptor on gastric emptying: concise communication

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · J. Nucl. Med.; (United States)

OSTI ID:5687210

Lamki, L; Sullivan, S

Animal and in vitro experiments suggest that opiates exert their actions by interaction with possibly five different subtypes of opiate receptors, identified as mu, kappa, sigma, delta, and epsilon. As yet there is no conclusive evidence for their existence in man. Our experiments on morphine and the enkephalin analog DAMME have suggested at least two types of opiate receptors involved in gastric secretion. In this study we have used the very powerful and nonselective opiate agonist etorphine to stimulate as many of the different opiate receptors as possible. We have then attempted to block selectively the ..mu.. receptor by administering a small dose of naloxone. Etorphine delayed gastric emptying whereas naloxone alone had no effect. In combination, the inhibitory effect of etorphine on gastric emptying was incompletely prevented while the subjective effects of etorphoine were completely abolished. These results may indicate that ..mu.. receptors are important in the regulation of gastric emptying, but that other (non-..mu..) receptors are also involved. The radionuclide study of gastric emptying, as used here, is a potentially powerful tool in physiological research on the gastrointestinal tract.

• Research Organization: Univ. of Western Ontario, London
• OSTI ID: 5687210
• Journal Information: J. Nucl. Med.; (United States), Vol. 24:8
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
GASTROINTESTINAL TRACT
PHYSIOLOGY
SCINTISCANNING
TECHNETIUM 99
CENTRAL NERVOUS SYSTEM AGENTS
ISOMERIC NUCLEI
MAN
NARCOTICS
RECEPTORS
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COUNTING TECHNIQUES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DRUGS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
NUCLEI
ODD-EVEN NUCLEI
PRIMATES
RADIOISOTOPE SCANNING
RADIOISOTOPES
TECHNETIUM ISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
551001 - Physiological Systems- Tracer Techniques