Tumor regression and histologic clearance after neutron brachytherapy for bulky localized cervical carcinoma
The response of bulky, advanced Stage IB and early Stage II carcinoma of the cervix to neutron brachytherapy (NT and radiotherapy) was studied using combined NT radiation) and extrafascial hysterectomy with histologic evaluation. Scheduling of neutron therapy relative to external beam photon therapy, tumor volume, tumor stage, tumor histology, and clinical tumor clearance were assessed in these studies. NT was easily combined with surgery in this study. Low stage tumors, small tumor volume and ''early'' neutron implants (scheduled within +/- one week of the start of fractionated radiation) showed more frequent histologic clearance of tumor. Long-term tumor control has been achieved and failures developed distant metastases without pelvic or local recurrence. This experience indicates that NT was effective for tumor clearance and control and represents a promising new modality for localized, advanced tumor therapy.
- Research Organization:
- Univ. of Kentucky Medical Center, Lexington
- OSTI ID:
- 5683763
- Journal Information:
- Cancer (Philadelphia); (United States), Vol. 50:12
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
NEUTRON THERAPY
RADIOTHERAPY
EVALUATION
UTERUS
EXTERNAL IRRADIATION
FRACTIONATED IRRADIATION
CALIFORNIUM 252
IRRADIATION PROCEDURES
PATIENTS
RADIATION SOURCE IMPLANTS
RADIOSENSITIVITY EFFECTS
RBE
SURGERY
SURVIVAL CURVES
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
BODY
CALIFORNIUM ISOTOPES
DISEASES
EVEN-EVEN NUCLEI
FEMALE GENITALS
HEAVY NUCLEI
IMPLANTS
IRRADIATION
ISOTOPES
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
NUCLEI
ORGANS
RADIATION SOURCES
RADIOISOTOPES
RADIOLOGY
THERAPY
YEARS LIVING RADIOISOTOPES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man