Approach to the development of a short-term whole-animal bioassay to distinguish initiating agents (incomplete carcinogens), promoting agents, complete carcinogens, and noncarcinogens in rat liver

Journal Article · Tue Jan 01 00:00:00 EST 1985 · J. Toxicol. Environ. Health; (United States)

DOI:https://doi.org/10.1080/15287398509530749· OSTI ID:5682737

Goldsworthy, T L; Pitot, H C

Utilizing data obtained from the published literature as well as further observations, the experimental findings reported in this paper serve to indicate an approach to the development of a short-term whole-animal bioassay capable of distinguishing agents that act at one or the other or both of the stages of initiation and promotion in rat liver. Because of the tissue specificity for both complete carcinogens and promoting agents, this bioassay system is not likely to identify the initiating and promoting capabilities of all carcinogenic agents and, thus, at present is not designed to replace the standard chronic bioassay systems. However, in view of the diverse metabolic capabilities of hepatic tissue, the system proposed may represent a model capable of distinguishing the stages of carcinogenesis at which many, if not most, specific carcinogenic chemicals exert their primary action. Test agents included diethylnitrosamine, dimethylbenzanthracene, proflavin, phenobarbital, butylated hydroxyanisole, 2,3,7,8-tetrachlorodibenzo-p-dioxin, and red beet betalain pigments.

• Research Organization: Univ. of Wisconsin, Madison
• OSTI ID: 5682737
• Journal Information: J. Toxicol. Environ. Health; (United States), Vol. 16:3-4
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANISOLE
CARCINOGEN SCREENING
BENZANTHRACENE
DIOXIN
NITROSAMINES
PHENOBARBITAL
PROFLAVINE
BIOLOGICAL MODELS
CARCINOGENS
LIVER
METABOLIC ACTIVATION
RATS
ACRIDINES
AMINES
ANESTHETICS
ANIMALS
ANTICONVULSANTS
AROMATICS
AZAARENES
AZINES
BARBITURATES
BODY
CENTRAL NERVOUS SYSTEM DEPRESSANTS
CONDENSED AROMATICS
DIGESTIVE SYSTEM
DRUGS
ETHERS
FLAVINES
GLANDS
HETEROCYCLIC COMPOUNDS
HYDROCARBONS
HYPNOTICS AND SEDATIVES
MAMMALS
MUTAGENS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PYRIDINES
PYRIMIDINES
RODENTS
SCREENING
VERTEBRATES
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)