Effect of certain variables on the tumor and tissue distribution of tracers. Salicylates and vasoactive drugs

Journal Article · Sun Mar 01 00:00:00 EST 1981 · Invest. Radiol.; (United States)

DOI:https://doi.org/10.1097/00004424-198103000-00008· OSTI ID:5681777

Halpern, S E; Hagan, P; Stern, P; Gordon, R; Dabbs, J

Attempts were made to increase the viable tumor concentration of 54Mn and 67Ga in a rat hepatoma model by administering rat angiotensin, tolazoline, and salicylates. Salicylates increased the tumor concentrations of 54Mn and improved 65Mn viable tumor/background ratios. 67Ga was not affected by the salicylates. The salicylate effect appeared to be mediated by intracellular mechanisms rather than alterations in plasma protein binding. Rat angiotensin slightly increased the concentrations of 67Ga in the tumors but not enough to suggest that it would be useful clinically. Tolazoline did not increase tumor uptake of the tracers.

• Research Organization: Veterans Administration Medical Center, San Diego, CA
• OSTI ID: 5681777
• Journal Information: Invest. Radiol.; (United States), Vol. 16:2
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANGIOTENSIN
BIOLOGICAL EFFECTS
BENZIMIDAZOLES
GALLIUM 67
BIOLOGICAL LOCALIZATION
MANGANESE 54
SALICYLIC ACID
DIAGNOSTIC USES
RADIONUCLIDE KINETICS
RATS
TISSUE DISTRIBUTION
TUMOR CELLS
ANIMAL CELLS
ANIMALS
AZOLES
BETA DECAY RADIOISOTOPES
CARBOXYLIC ACIDS
CARDIOVASCULAR AGENTS
DAYS LIVING RADIOISOTOPES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
GALLIUM ISOTOPES
GLOBULINS
HETEROCYCLIC COMPOUNDS
HYDROXY ACIDS
IMIDAZOLES
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MANGANESE ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PROTEINS
RADIOISOTOPES
RODENTS
USES
VASOCONSTRICTORS
VERTEBRATES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550301 - Cytology- Tracer Techniques
560172 - Radiation Effects- Nuclide Kinetics & Toxicology- Animals- (-1987)