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Title: Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor

Abstract

C3H/HeN female mice were exposed to whole-body cobalt-60 radiation and administered soluble glucan (5 mg i.v. at 1 h following exposure), recombinant human granulocyte colony-stimulating factor or both agents. Treatments were evaluated for their ability to enhance hemopoietic regeneration, and to increase survival after radiation-induced myelosuppression. Both glucan and G-CSF enhanced hemopoietic regeneration alone; however, greater effects were observed in mice receiving both agents. For example, on day 17 following a sublethal 6.5-Gy radiation exposure, mice treated with saline, G-CSF, glucan, or both agents, respectively, exhibited 36%, 65%, 50%, and 78% of normal bone marrow cellularity, and 84%, 175%, 152%, and 212% of normal splenic cellularity.

Authors:
; ; ;
Publication Date:
Research Org.:
Armed Forces Radiobiology Research Inst., Bethesda, MD (USA)
OSTI Identifier:
5681219
Report Number(s):
AD-A-230978/9/XAB; AFRRI-SR-90-36
Resource Type:
Technical Report
Resource Relation:
Other Information: Pub. in Experimental Hematology, v18 p1042-1048 1990
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; GROWTH FACTORS; RADIOSENSITIVITY EFFECTS; HEMATOPOIETIC SYSTEM; BIOLOGICAL REGENERATION; PROTEINS; BIOLOGICAL RADIATION EFFECTS; BONE MARROW; COBALT 60; IMMUNOSUPPRESSION; MICE; SURVIVAL TIME; ANIMAL TISSUES; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BIOLOGICAL RECOVERY; BODY; COBALT ISOTOPES; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; MAMMALS; MINUTES LIVING RADIOISOTOPES; MITOGENS; NUCLEI; ODD-ODD NUCLEI; ORGANIC COMPOUNDS; ORGANS; RADIATION EFFECTS; RADIOISOTOPES; RECOVERY; RODENTS; TISSUES; VERTEBRATES; YEARS LIVING RADIOISOT; 560152* - Radiation Effects on Animals- Animals

Citation Formats

Patchen, M L, MacVittie, T J, Solberg, B D, and Souza, L M. Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor. United States: N. p., 1990. Web.
Patchen, M L, MacVittie, T J, Solberg, B D, & Souza, L M. Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor. United States.
Patchen, M L, MacVittie, T J, Solberg, B D, and Souza, L M. 1990. "Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor". United States.
@article{osti_5681219,
title = {Survival enhancement and hemopoietic regeneration following radiation exposure: therapeutic approach using glucan and granulocyte colony-stimulating factor},
author = {Patchen, M L and MacVittie, T J and Solberg, B D and Souza, L M},
abstractNote = {C3H/HeN female mice were exposed to whole-body cobalt-60 radiation and administered soluble glucan (5 mg i.v. at 1 h following exposure), recombinant human granulocyte colony-stimulating factor or both agents. Treatments were evaluated for their ability to enhance hemopoietic regeneration, and to increase survival after radiation-induced myelosuppression. Both glucan and G-CSF enhanced hemopoietic regeneration alone; however, greater effects were observed in mice receiving both agents. For example, on day 17 following a sublethal 6.5-Gy radiation exposure, mice treated with saline, G-CSF, glucan, or both agents, respectively, exhibited 36%, 65%, 50%, and 78% of normal bone marrow cellularity, and 84%, 175%, 152%, and 212% of normal splenic cellularity.},
doi = {},
url = {https://www.osti.gov/biblio/5681219}, journal = {},
number = ,
volume = ,
place = {United States},
year = {Mon Jan 01 00:00:00 EST 1990},
month = {Mon Jan 01 00:00:00 EST 1990}
}

Technical Report:
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