Influence of some anti-inflammatory drugs on the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content

Journal Article · Fri Jun 01 00:00:00 EDT 1990 · Environmental Research; (United States)

DOI:https://doi.org/10.1016/S0013-9351(05)80152-5· OSTI ID:5679009

Mostafa, M H; Sheweita, S A; Abdel-Moneam, N M ^[1]

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1. Alexandria Univ. (Egypt)

The metabolism of benzo({alpha})pyrene is mediated by the mixed function oxidase system including the cytochrome P450-dependent aryl hydrocarbon hydroxylase. The data of the present study revealed the ability of various commonly used anti-inflammatory drugs to alter the activity of this enzyme system, where all the tested drugs, namely phenyl butazone, ketoprofen, piroxicam, and acetaminophen, caused an increase in both the activity of aryl hydrocarbon hydroxylase and the cytochrome P450 content whether administered as a single dose or as a repeated dose for 6 consecutive days. The percentage of change for all drugs except phenyl butazone was proportional to the duration of drug administration. On the other hand, pyrazole which is chemically related to phenyl butazone, had no significant effect when administered as a single dose but caused a decrease in both studied parameters when administered as a repeated dose for 6 consecutive days. The mechanisms by which these commonly used drugs modify the aryl hydrocarbon hydroxylase activity and the cytochrome p450 content are discussed in the text.

• OSTI ID: 5679009
• Journal Information: Environmental Research; (United States), Vol. 52:1; ISSN 0013-9351
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ARYL 4-MONOOXYGENASE
BIOCHEMICAL REACTION KINETICS
CENTRAL NERVOUS SYSTEM DEPRESSANTS
ANALGESICS
ANTIPYRETICS
BENZOPYRENE
CYTOCHROME OXIDASE
DOSE-RESPONSE RELATIONSHIPS
ENZYME ACTIVITY
METABOLISM
AROMATICS
CONDENSED AROMATICS
DRUGS
ENZYMES
HAEM DEHYDROGENASES
HYDROCARBONS
KINETICS
ORGANIC COMPOUNDS
OXIDOREDUCTASES
PROTEINS
REACTION KINETICS
560300* - Chemicals Metabolism & Toxicology