Gastrointestinal absorption of plutonium, uranium and neptunium in fed and fasted adult baboons: Application to humans

Technical Report · Sun Mar 01 00:00:00 EST 1992

OSTI ID:5678359

Bhattacharyya, M H; Larsen, R P; Oldham, R D; Moretti, E S ^[1]; Cohen, N; Ralston, L G; Ayres, L ^[2]

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1. Argonne National Lab., IL (United States)
2. New York Univ. Medical Center, Tuxedo, NY (United States)

Gastrointestinal (GI) absorption values of plutonium, uranium, and neptunium were determined in fed and fasted adult baboons. A dual isotope method of determining GI absorption, which does not require animal sacrifice, was validated and shown to compare well with the sacrifice method (summation of oral isotope in urine with that in tissues at sacrifice). For all three elements, mean GI absorption values were significantly high (5- to 50-fold) in 24-hour (h)-fasted animals than in fed animals, and GI absorption values for baboons agreed well with those for humans.

• Research Organization: Nuclear Regulatory Commission, Washington, DC (United States). Div. of Regulatory Applications; Argonne National Lab., IL (United States)
• Sponsoring Organization: USNRC; Nuclear Regulatory Commission, Washington, DC (United States)
• DOE Contract Number: W-31109-ENG-38
• OSTI ID: 5678359
• Report Number(s): NUREG/CR-5842; ANL-92/8; ON: TI92010486
• Country of Publication: United States
• Language: English

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