Plasma exudation. Correlation between Evans blue dye and radiolabeled albumin in guinea pig airways in vivo

Journal Article · Sat Jul 01 00:00:00 EDT 1989 · Journal of Pharmacological Methods; (USA)

DOI:https://doi.org/10.1016/0160-5402(89)90068-5· OSTI ID:5673444

Rogers, D F; Boschetto, P; Barnes, P J ^[1]

---

1. National Heart Lung Institute, London (England)

We quantified the tissue exudation and luminal transudation of two plasma markers, Evans blue (EB) dye and ({sup 125}I)-human serum albumin (HSA), into the airways of the anesthetized guinea pig in response to platelet activating factor (PAF). There was a highly significant correlation between the tissue content of EB and ({sup 125}I)-HSA in all airways studied. Significant correlation for transudation of the two markers was limited to high rates of plasma leakage. ({sup 125}I)-HSA was the more sensitive marker for the association between exudation and transudation and the effect of PAF on transudation. EB was the better marker for assessing the relationship between the dose of PAF and plasma exudation.

• OSTI ID: 5673444
• Journal Information: Journal of Pharmacological Methods; (USA), Vol. 21:4; ISSN 0160-5402
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL MARKERS
CORRELATIONS
BLOOD COAGULATION FACTORS
BIOCHEMICAL REACTION KINETICS
ALBUMINS
ASTHMA
BRONCHI
EVANS BLUE
GUINEA PIGS
LABELLED COMPOUNDS
LARYNX
LUNGS
TRACER TECHNIQUES
TRACHEA
ANIMALS
AZO COMPOUNDS
AZO DYES
BODY
COAGULANTS
DISEASES
DRUGS
DYES
HEMATOLOGIC AGENTS
ISOTOPE APPLICATIONS
KINETICS
MAMMALS
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
PROTEINS
REACTION KINETICS
REAGENTS
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
RODENTS
SULFONIC ACIDS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques