Cesium in mammals: acute toxicity, organ changes and tissue accumulation

Journal Article · Thu Jan 01 00:00:00 EST 1981 · J. Environ. Sci. Health, Part A; (United States)

DOI:https://doi.org/10.1080/10934528109375003· OSTI ID:5672245

Pinsky, C ^[1]; Bose, R; Taylor, J R; McKee, J S.C.; Lapointe, C; Birchall, J

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1. Univ. of Manitoba, Winnipeg, Canada

The acute toxicity of cesium given intraperitoneally (IP) as CsCl in mice is characterized by autonomic upset and by a multiphasic excitant-depressant action on the central nervous system. The predominantly depressant action can progress to respiratory embarrassment, cyanosis, spinal convulsions and death. Light microscopy of mice treated with 2.0 mEq Cs/sup +/ kg/sup -1/ IP for 14 days showed lymphoid hyperplasia in small intestine. Measurement of tissue cesium by the proton-induced x-ray emission (PIXE) technique is convenient and reproducible. Cesium displays a generalized bioactivity that merits further study.

• OSTI ID: 5672245
• Journal Information: J. Environ. Sci. Health, Part A; (United States), Vol. A16:5
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CESIUM
BIOLOGICAL ACCUMULATION
TOXICITY
ACUTE EXPOSURE
BIOLOGICAL EFFECTS
CENTRAL NERVOUS SYSTEM
CESIUM CHLORIDES
INTRAPERITONEAL INJECTION
LYMPHATIC SYSTEM
MICE
NERVOUS SYSTEM DISEASES
PIXE ANALYSIS
RESPIRATORY SYSTEM DISEASES
SMALL INTESTINE
ALKALI METAL COMPOUNDS
ALKALI METALS
ANIMALS
BODY
CESIUM COMPOUNDS
CHEMICAL ANALYSIS
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
DISEASES
ELEMENTS
GASTROINTESTINAL TRACT
HALIDES
HALOGEN COMPOUNDS
INJECTION
INTAKE
INTESTINES
MAMMALS
METALS
NERVOUS SYSTEM
NONDESTRUCTIVE ANALYSIS
ORGANS
RODENTS
VERTEBRATES
X-RAY EMISSION ANALYSIS
560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)