Chronic pyelonephritis: Modulation of host defenses by cyclosporin A

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Journal of Laboratory and Clinical Medicine; (USA)

OSTI ID:5669742

Findon, G; Miller, T E ^[1]

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1. Auckland Hospital (New Zealand)

Chronic experimental pyelonephritis is characterized by a stable level of infection, which persists for many months. Administration of cyclosporin A (CsA) reactivated previously healed renal lesions and caused a marked increase in bacterial numbers in the kidney. Studies were then carried out to compare the effects of CsA, and the nonselective cytodepletive agents irradiation and cyclophosphamide, on both host defenses and the bacteriologic status of chronically infected kidneys. Two different responses were observed. In animals treated with CsA, bacterial numbers increased markedly, although circulating neutrophil numbers were relatively unaffected. This observation was in contrast to the severe ablation of leukocyte numbers and competence needed to achieve an equivalent effect when irradiation and cyclophosphamide were used. One possible explanation for the adverse effect of CsA on the host-parasite balance in chronic pyelonephritis is that CsA affects mediators that control the inflammatory response or induces a qualitative change in a critical cellular defense compartment.

• OSTI ID: 5669742
• Journal Information: Journal of Laboratory and Clinical Medicine; (USA), Vol. 114:2; ISSN 0022-2143
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
IMMUNOSUPPRESSIVE DRUGS
BIOLOGICAL EFFECTS
NEPHRITIS
COMBINED THERAPY
COMPARATIVE EVALUATIONS
ENDOXAN
ESCHERICHIA COLI
KIDNEYS
LEUKOCYTES
NEUTROPHILS
RATS
ALKYLATING AGENTS
ANIMALS
BACTERIA
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
DISEASES
DRUGS
MAMMALS
MATERIALS
MICROORGANISMS
ORGANS
RODENTS
THERAPY
UROGENITAL SYSTEM DISEASES
VERTEBRATES
550603* - Medicine- External Radiation in Therapy- (1980-)
550600 - Medicine