The effects of inhaled sulfuric acid on pulmonary function in adolescent asthmatics

Journal Article · Mon Aug 01 00:00:00 EDT 1983 · Am. Rev. Respir. Dis.; (United States)

OSTI ID:5669568

Koenig, J Q; Pierson, W E; Horike, M

Ten adolescent subjects with extrinsic asthma and exercise-induced bronchospasm were studied. The subjects were exposed for 30 min at rest followed by 10 min during moderate exercise on a treadmill to either 100 micrograms/m3 sodium chloride (NaCl) or 100 micrograms/m3 sulfuric acid (H/sub 2/SO/sub 4/) droplet aerosols. All exposures were at approximately 75% relative humidity and 22 degrees C. Pulmonary functional measurements were recorded before, during, and after exposure while the subject was seated in a body plethysmograph. Exposure to the NaCl aerosol during exercise produced a small (12%) but significant drop in maximal expiratory flow (V/sub max/75) (p less than 0.05). However, exposure to the H/sub 2/SO/sub 4/ aerosol produced larger reductions in V/sub max/75 (29%; p less than 0.01) and also significant changes in 3 other parameters of pulmonary function: V/sub max/50, FEV1, and total respiratory resistance (RT). The changes were similar to those reported for exposure to 0.5 ppm of sulfur dioxide in a similar group of adolescents with extrinsic asthma. Our results are the first report of reversible pulmonary functional changes after H/sub 2/SO/sub 4/ exposure in a group of adolescent asthmatic subjects.

• Research Organization: Department of Environmental Health, University of Washington, Seattle
• OSTI ID: 5669568
• Journal Information: Am. Rev. Respir. Dis.; (United States), Vol. 128:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LUNGS
DYNAMIC FUNCTION STUDIES
SULFURIC ACID
BIOLOGICAL EFFECTS
ADOLESCENTS
AEROSOLS
AIR POLLUTION
ASTHMA
EXERCISE
HUMIDITY
PATIENTS
SODIUM CHLORIDES
SULFUR DIOXIDE
AGE GROUPS
ALKALI METAL COMPOUNDS
BODY
CHALCOGENIDES
CHLORIDES
CHLORINE COMPOUNDS
COLLOIDS
DISEASES
DISPERSIONS
HALIDES
HALOGEN COMPOUNDS
HYDROGEN COMPOUNDS
INORGANIC ACIDS
ORGANS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
RESPIRATORY SYSTEM
RESPIRATORY SYSTEM DISEASES
SODIUM COMPOUNDS
SOLS
SULFUR COMPOUNDS
SULFUR OXIDES
560306* - Chemicals Metabolism & Toxicology- Man- (-1987)