Cerebellar glucose consumption in normal and pathologic states using fluorine-FDG and PET

Journal Article · Sun Nov 01 00:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:5669076

Kushner, M; Tobin, M; Alavi, A; Chawluk, J; Rosen, M; Fazekas, F; Alavi, J; Reivich, M

We studied cerebellar metabolism in 118 subjects including young and elderly controls and patients suffering from stroke, supratentorial brain tumor and Alzheimer's disease using fluorine-18 fluorodeoxyglucose ((/sup 18/F)FDG) and position emission tomography (PET). Alzheimer's disease and normal aging did not alter mean cerebellar metabolism. In stroke and tumor mean cerebellar metabolism was lower in the hemisphere contralateral to the supratentorial lesion. In tumor bilaterally significant reductions in absolute cerebellar metabolism also were noted, unlike stroke. Primary sensory stimulation did not alter absolute or relative cerebellar metabolism. These results show that absolute and relative values for cerebellar metabolism vary depending on the process under study. Thus, analysis schemes employing normalization of regional metabolic data to cerebellar values may be subject to error.

• Research Organization: Univ. of Pennsylvania, Philadelphia
• OSTI ID: 5669076
• Journal Information: J. Nucl. Med.; (United States), Vol. 28:11
• Country of Publication: United States
• Language: English

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62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY
GLUCOSE
METABOLISM
CEREBELLUM
FLUORINE 18
NERVOUS SYSTEM DISEASES
SENSE ORGANS
VASCULAR DISEASES
ALDEHYDES
BETA DECAY RADIOISOTOPES
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CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
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FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
ISOTOPES
LIGHT NUCLEI
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
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