Liver disease associated with exposure to 1,1,1-trichloroethane

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Archives of Internal Medicine; (USA)

DOI:https://doi.org/10.1001/archinte.149.8.1793· OSTI ID:5668293

Hodgson, M J; Heyl, A E; Van Thiel, D H ^[1]

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1. Univ. of Pittsburgh School of Medicine, PA (USA)

1,1,1-trichloroethane is a halogenated hydrocarbon solvent commonly used in industry because of its supposed lack of hepatotoxicity. Nonetheless, animal studies performed by several independent groups have shown the solvent to induce fat deposition, vacuolar degeneration, and centrilobular necrosis, changes similar to those seen after exposure to carbon tetrachloride, albeit of a much reduced magnitude, in animals exposed to the agent. Four patients with fatty liver disease whose work entailed substantial exposure to this agent were seen at the University of Pittsburgh (Pa). Based on this clinical experience, we believe that 1,1,1-trichloroethane should be reconsidered as an agent with potential hepatotoxicity in man. 62 references.

• OSTI ID: 5668293
• Journal Information: Archives of Internal Medicine; (USA), Vol. 149:8; ISSN 0003-9926
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CHLORINATED ALIPHATIC HYDROCARBONS
TOXICITY
LIVER CIRRHOSIS
EPIDEMIOLOGY
LIVER
OCCUPATIONAL DISEASES
OCCUPATIONAL EXPOSURE
PERSONNEL
REVIEWS
SOLVENTS
BODY
DIGESTIVE SYSTEM
DIGESTIVE SYSTEM DISEASES
DISEASES
DOCUMENT TYPES
GLANDS
HALOGENATED ALIPHATIC HYDROCARBONS
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
560300* - Chemicals Metabolism & Toxicology