In vivo studies on the binding of heparin and its fractions with platelet factor 4

Journal Article · Tue Jan 01 00:00:00 EST 1985 · Semin. Thromb. Hemostasis; (United States)

DOI:https://doi.org/10.1055/s-2007-1004358· OSTI ID:5666158

Walz, D A; Hung, G L

PF4 has a half-life in plasma of less than 3 minutes, and its rapid clearance appears to be a function of binding to the vascular endothelium. Once bound to the endothelium, PF4 can be released by heparin in a time-dependent manner; recovery is greater the sooner heparin is administered following PF4 infusion. This heparin-induced release of PF4 can be abolished if the heparin is first complexed with hexadimethrine bromide. Likewise, this heparin-induced release of PF4 is dependent upon the type of heparin used; low molecular weight heparin fractions and fragments do not cause the PF4 rebound seen with intact heparin. Thus, it would appear that low molecular weight forms of heparin are advantageous in that their in vivo administration would not be mediated by such platelet modulators as PF4.

• Research Organization: Wayne State Univ. School of Medicine, Detroit, MI
• OSTI ID: 5666158
• Journal Information: Semin. Thromb. Hemostasis; (United States), Vol. 11:1
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
HEPARIN
CHEMICAL BONDS
BIOLOGICAL HALF-LIFE
BLOOD PLATELETS
BLOOD-PLASMA CLEARANCE
ENDOTHELIUM
IN VIVO
RADIOIMMUNOASSAY
STRUCTURE-ACTIVITY RELATIONSHIPS
TIME DEPENDENCE
AMINES
ANIMAL TISSUES
ANTICOAGULANTS
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CARBOHYDRATES
CLEARANCE
DRUGS
HEMATOLOGIC AGENTS
ISOTOPE APPLICATIONS
MATERIALS
MUCOPOLYSACCHARIDES
ORGANIC COMPOUNDS
ORGANIC SULFUR COMPOUNDS
POLYSACCHARIDES
RADIOASSAY
SACCHARIDES
TISSUES
TRACER TECHNIQUES
550201* - Biochemistry- Tracer Techniques