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Title: Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages

Abstract

This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorlyase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.

Authors:
; ; ;
Publication Date:
Research Org.:
Medical College of Georgia, Augusta
OSTI Identifier:
5661845
Resource Type:
Journal Article
Journal Name:
Environ. Res.; (United States)
Additional Journal Information:
Journal Volume: 36:2
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; CYTOCHROME OXIDASE; ENZYME ACTIVITY; MERCURY; TOXICITY; OXIDOREDUCTASES; ACETATES; EXPERIMENTAL DATA; FETAL MEMBRANES; FETUSES; HAMSTERS; KIDNEYS; PREGNANCY; SINGLE INTAKE; TIME DEPENDENCE; URINE; ANIMALS; BIOLOGICAL MATERIALS; BIOLOGICAL WASTES; BODY; BODY FLUIDS; CARBOXYLIC ACID SALTS; DATA; ELEMENTS; ENZYMES; HAEM DEHYDROGENASES; INFORMATION; INTAKE; MAMMALS; MATERIALS; MEMBRANES; METALS; NUMERICAL DATA; ORGANS; RODENTS; VERTEBRATES; WASTES; 560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)

Citation Formats

Karp, W B, Gale, T F, Subramanyam, S B, and DuRant, R H. Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages. United States: N. p., 1985. Web. doi:10.1016/0013-9351(85)90030-1.
Karp, W B, Gale, T F, Subramanyam, S B, & DuRant, R H. Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages. United States. https://doi.org/10.1016/0013-9351(85)90030-1
Karp, W B, Gale, T F, Subramanyam, S B, and DuRant, R H. 1985. "Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages". United States. https://doi.org/10.1016/0013-9351(85)90030-1.
@article{osti_5661845,
title = {Effect of mercuric acetate on selected enzymes of maternal and fetal hamsters at different gestational ages},
author = {Karp, W B and Gale, T F and Subramanyam, S B and DuRant, R H},
abstractNote = {This study establishes levels of activity of glucose-6-phosphate dehydrogenase (G6PD), glycogen phosphorlyase (GP), and cytochrome c oxidase (cyt c ox) in maternal, placental, and fetal tissues at Days 9, 12, and 15 in the 16-day gestation period of the hamster, and following a single dose of either 8 or 15 mg/kg mercuric acetate on the eighth gestational day. Mercury significantly elevated maternal kidney G6PD activity and decreased GP activity. The increase in kidney G6PD strongly correlated with observed urine and kidney abnormalities.},
doi = {10.1016/0013-9351(85)90030-1},
url = {https://www.osti.gov/biblio/5661845}, journal = {Environ. Res.; (United States)},
number = ,
volume = 36:2,
place = {United States},
year = {Mon Apr 01 00:00:00 EST 1985},
month = {Mon Apr 01 00:00:00 EST 1985}
}