Response of mouse lung to irradiation at different dose-rates

Hill, R P

doi:10.1016/0360-3016(83)90395-4

Title: Response of mouse lung to irradiation at different dose-rates

Full Record
Other Related Research

Abstract

Groups of LAF1 mice were given thoracic irradiation using /sup 60/Co ..gamma..-rays at dose-rates of 0.05 Gy/min (LDR) or 1.1 Gy/min (HDR) and the death of the animals was monitored as a function of time. It was found that the time pattern of animal deaths was similar for the two different dose-rates. Dose response curves for animals dying at various times up to 500 days after irradiation were calculated and the LD/sub 50/ values determined. The curves for the LD/sub 50/ values, plotted as a function of the time at analysis for treatment at HDR or LDR, were essentially parallel to each other but separated by a factor (LDR/HDR) of about 1.8. This indicates that the sparing effect of LDR treatment is the same for deaths occurring during the early pneumonitis phase or during the late fibrotic phase of lung damage. The available information on the response of patients to whole thoracic irradiation, given for either palliation or piror to bone marrow transplantation, suggests that for similar dose-rates to those studied here the ratio (LDR/HDR) is only 1.2 to 1.3. This difference between the animal and human data may reflect the modifying effect of the large doses of cytotoxic drugsmore »« less

Authors:: Hill, R P

Publication Date:: Fri Jul 01 00:00:00 EDT 1983

Research Org.:: Princess Margaret Hospital, Toronto, Ontario

OSTI Identifier:: 5661690

Resource Type:: Journal Article

Journal Name:: Int. J. Radiat. Oncol., Biol. Phys.; (United States)

Additional Journal Information:: Journal Volume: 9:7

Country of Publication:: United States

Language:: English

Subject:: 63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; 59 BASIC BIOLOGICAL SCIENCES; FIBROSIS; RADIOINDUCTION; LUNGS; BIOLOGICAL RADIATION EFFECTS; PNEUMONITIS; COBALT 60; DOSE RATES; GAMMA RADIATION; LETHAL RADIATION DOSE; MICE; ANIMALS; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BIOLOGICAL EFFECTS; BODY; COBALT ISOTOPES; DOSES; ELECTROMAGNETIC RADIATION; INTERMEDIATE MASS NUCLEI; INTERNAL CONVERSION RADIOISOTOPES; IONIZING RADIATIONS; ISOMERIC TRANSITION ISOTOPES; ISOTOPES; LETHAL DOSES; MAMMALS; MINUTES LIVING RADIOISOTOPES; NUCLEI; ODD-ODD NUCLEI; ORGANS; PATHOLOGICAL CHANGES; RADIATION DOSES; RADIATION EFFECTS; RADIATIONS; RADIOISOTOPES; RESPIRATORY SYSTEM; RODENTS; VERTEBRATES; YEARS LIVING RADIOISOTOPES; 560152* - Radiation Effects on Animals- Animals; 550900 - Pathology

Citation Formats


                    Hill, R P. Response of mouse lung to irradiation at different dose-rates.  United States: N. p., 1983. 
        Web.  doi:10.1016/0360-3016(83)90395-4.

Copy to clipboard


                    Hill, R P. Response of mouse lung to irradiation at different dose-rates.  United States.  https://doi.org/10.1016/0360-3016(83)90395-4

Copy to clipboard


                    Hill, R P. 1983.  
        "Response of mouse lung to irradiation at different dose-rates".  United States.  https://doi.org/10.1016/0360-3016(83)90395-4.

Copy to clipboard


                    
@article{osti_5661690,

  title        = {Response of mouse lung to irradiation at different dose-rates},

  author       = {Hill, R P},

  abstractNote = {Groups of LAF1 mice were given thoracic irradiation using /sup 60/Co ..gamma..-rays at dose-rates of 0.05 Gy/min (LDR) or 1.1 Gy/min (HDR) and the death of the animals was monitored as a function of time. It was found that the time pattern of animal deaths was similar for the two different dose-rates. Dose response curves for animals dying at various times up to 500 days after irradiation were calculated and the LD/sub 50/ values determined. The curves for the LD/sub 50/ values, plotted as a function of the time at analysis for treatment at HDR or LDR, were essentially parallel to each other but separated by a factor (LDR/HDR) of about 1.8. This indicates that the sparing effect of LDR treatment is the same for deaths occurring during the early pneumonitis phase or during the late fibrotic phase of lung damage. The available information on the response of patients to whole thoracic irradiation, given for either palliation or piror to bone marrow transplantation, suggests that for similar dose-rates to those studied here the ratio (LDR/HDR) is only 1.2 to 1.3. This difference between the animal and human data may reflect the modifying effect of the large doses of cytotoxic drugs used in combination with the irradiation of bone marrow transplant patients.},

  doi          = {10.1016/0360-3016(83)90395-4},

  url          = {https://www.osti.gov/biblio/5661690},
  journal      = {Int. J. Radiat. Oncol., Biol. Phys.; (United States)},
number       = ,

  volume       = 9:7,

  place        = {United States},

  year         = {Fri Jul 01 00:00:00 EDT 1983},

  month        = {Fri Jul 01 00:00:00 EDT 1983}

}

Copy to clipboard

Journal Article:

https://doi.org/10.1016/0360-3016(83)90395-4

Other availability

Find in Google Scholar

Search WorldCat to find libraries that may hold this journal

Save / Share:

Export Metadata

Save to My Library

Similar records in OSTI.GOV collections:

Lung damage following bone marrow transplantation. I. The contribution of irradiation. [Rats]

Journal Article Cardozo, B; Zoetelief, H; van Bekkum, D; ... - Int. J. Radiat. Oncol., Biol. Phys.; (United States)

High dose whole body irradiation is commonly included in conditioning regimens for bone marrow transplantation for treatment of patients with hematological malignancies. Interstitial pneumonitis is a major complication after BMT. When no infectious cause is found, it is classified as idiopathic IP (IIP). Total body irradiation is often associated with the induction of IIP; however, extrapolation of animal data from the experiments presented indicates that this is not the only factor contributing to IIP in man. Brown Norway (BN/Bi) rats were bilaterally irradiated to the lungs with 300 kV X rays at a high dose rate (HDR; 0.8 Gy/min) andmore »« less
https://doi.org/10.1016/0360-3016(85)90112-9
Lung damage following bone marrow transplantation. II. The contribution of cyclophosphamide

Journal Article Varekamp, A; de Vries, A; Zurcher, C; ... - Int. J. Radiat. Oncol., Biol. Phys.; (United States)

The effect of high-dose cyclophosphamide (Cy), either alone or in combination with irradiation, upon the development of interstitial pneumonitis (IP) after bone marrow transplantation (BMT) was investigated in a Brown Norway rat model. The parameters that were examined included ventilation rate, mortality, and histopathology. No damage to the lungs was observed in rats given Cy alone in supralethal dosages plus BMT, and mortality resulted from severe aplasia of hemopoietic and lymphoid tissues with multifocal hemorrhages, secondary infections, and sepsis. Two separate periods of mortality were observed within the first 180 days following whole thorax irradiation with a high dose ratemore »« less
https://doi.org/10.1016/0360-3016(87)90319-1
Early and late pulmonary toxicity in mice evaluated 180 and 420 days following localized lung irradiation

Journal Article Siemann, D; Hill, R; Penney, D - Radiat. Res.; (United States)

The lungs of 2 to 3-month-old female C3H/HeJ and 6-month-old male LAF1 mice were locally irradiated with graded doses of radiation ranging from 900 to 1800 rad. The patterns of animal details for times up to 60 weeks after irradiation were recorded. Over this period mice in all the irradiated groups continued to die. However, the onset of animal deaths was dose dependent such that lethality occurred earlier after the higher radiation doses. Whereas mice receiving large radiation doses started to die by 75-100 days post-treatment, few or no animal deaths occurred in those groups receiving the lowest doses untilmore »« less
https://doi.org/10.2307/3575784
The effect of dose rate and adriamycin on the tolerance of thoracic radiation in mice

Journal Article Sherman, D; Carabell, S; Belli, J - Int. J. Radiat. Oncol., Biol. Phys.; (United States)

Radiation damage to the lung may be a predisposing factor in the development of interstitial pneumonitis in patients undergoing total body radiation and subsequent bone marrow transplantation in the treatment of leukemia. Adriamycin has been used in conjunction with bone marrow transplantation, and has also been shown to interact with radiation. This experiment was designed to study the effects of pre-administration of adriamycin on the radiation tolerance of the lung and esophagus. Mice were irradiated at 5 rad; 15 rad or 70 rad per minute to the upper body, 24 hours or 7 days after adriamycin. Oral esophageal death occurredmore »« less
https://doi.org/10.1016/0360-3016(82)90383-2
The effect of dose rate and adriamycin on the tolerance of thoracic radiation in mice

Journal Article Sherman, D; Carabell, S; Belli, J; ... - Int. J. Radiat. Oncol., Biol. Phys.; (United States)

Radiation damage to the lung may be a predisposing factor in the development of interstitial pneumonitis in patients undergoing total body radiation and subsequent bone marrow transplantation in the treatment of leukemia. Adriamycin has been used in conjunction with bone marrow transplantation, and has also been shown to interact with radiation. This experiment was designed to study the effects of pre-administration of adriamycin on the radiation tolerance of the lung and esophagus. Mice were irradiated at 5 rad; 15 rad or 70 rad per minute to the upper body, 24 hours or 7 days after adriamycin. Oral esophageal death occurredmore »« less
https://doi.org/10.1016/0360-3016(82)90383-2

Similar Records