Expression of resistance to Friend virus-stimulated erythropoiesis in bone marrow chimeras containing Fv-2rr and Fv-2ss bone marrow
Bone marrow chimeras were formed containing mixtures of DBA/2 (Fv-2ss, Hbbdd) and B10.D2 (Fv-2rr, Hbbss) bone marrow. When these mice were infected with the polycythemia-inducing strain of Friend virus, erythropoiesis was stimulated, but the proportion of B10.D2 hemoglobin fell rapidly and newly synthesized hemoglobin was essentially all of the DBA/2 type. The treatment of infected polycythemic chimeras with phenylhydrazine lowered the hematocrit and restored the synthesis of B10.D2 hemoglobin. These results imply that B10.D2 erythroid precursors are intrinsically resistant to Friend virus-stimulated erythropoiesis. The experiments also suggest that virus-stimulated erythropoiesis is not mediated by a factor or cell-cell interactions, unless such factors or interactions do not act across strain barriers.
- OSTI ID:
- 5658688
- Journal Information:
- J. Exp. Med.; (United States), Vol. 154:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHIMERAS
PHYSIOLOGY
ERYTHROPOIESIS
STIMULATION
ANTIGENS
BONE MARROW
ELECTROPHORESIS
HEMOGLOBIN
MICE
VIRUSES
ANIMAL TISSUES
ANIMALS
BLOOD FORMATION
BODY
CARBOXYLIC ACIDS
GLOBIN
HEMATOPOIETIC SYSTEM
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
MAMMALS
MICROORGANISMS
MOSAICISM
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PARASITES
PIGMENTS
PORPHYRINS
PROTEINS
RODENTS
TISSUES
VERTEBRATES
551000* - Physiological Systems
550300 - Cytology