DNA damage in human skin fibroblasts exposed to UVA light used in clinical PUVA treatment

Journal Article · Mon Jun 01 00:00:00 EDT 1981 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12521078· OSTI ID:5657986

Bredberg, A

Human skin fibroblasts were irradiated with a clinically used UVA light source. The doses (1.1 and 3 J/cm2) were similar to those reaching the dermis during clinical PUVA treatment of psoriasis. DNA strand breaks, as determined by alkaline elution, were formed in a dose-dependent way and disappeared within 1 hr of postincubation at 37 degrees C. These findings have clinical implications since UVA-induced DNA damage may be accompanied by mutagenic and tumor promoting effects.

• OSTI ID: 5657986
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 76:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
DNA
BIOLOGICAL RADIATION EFFECTS
FIBROBLASTS
DOSE-RESPONSE RELATIONSHIPS
MAN
MUTAGENESIS
PSORALEN
PSORIASIS
RADIATION DOSES
RADIOTHERAPY
SIDE EFFECTS
SKIN
STRAND BREAKS
TUMOR PROMOTERS
ULTRAVIOLET RADIATION
ANIMAL CELLS
ANIMALS
ANTICOAGULANTS
BIOLOGICAL EFFECTS
BODY
CONNECTIVE TISSUE CELLS
COUMARINS
DISEASES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
HEMATOLOGIC AGENTS
HETEROCYCLIC COMPOUNDS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
NUCLEIC ACIDS
ORGANIC COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANS
PRIMATES
PROMOTERS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
SKIN DISEASES
SOMATIC CELLS
THERAPY
VERTEBRATES
560151* - Radiation Effects on Animals- Man
560152 - Radiation Effects on Animals- Animals
550300 - Cytology
550200 - Biochemistry