Biologically available iodine in goitrogenic diets
Eight different sources of low-iodine diet (LID) were tested in mice over 14 years. The available iodine in each diet was measured by isotopic equilibration. Commercially prepared Remington diets contained 6.8 to 69.3 ng available iodine/g, and the results were usually different from shipment to shipment. Some samples produced greatly enlarged thyroids. The Remington diets from two sources were occasionally low in iodine but produced little thyroid enlargement. Between 1977 and 1980 only one shipment of Remington diet was found to contain less than 10 ng available I/g, and it resulted in large goiters. Since 1980 other compositions of LID have been used, but they caused additional abnormalities during breeding or chronic feeding. A low-iodine wheat diet produced goiter in mice more readily than in rats. In the course of testing for unavailable forms of dietary iodine, it was found that only 34.2% of thyroxine iodine was available to the thyroid iodine pool of mice. It is concluded that unidentified nutritional deficiency or dietary contaminants can alter the goitrogenic response to restricted iodine intake. Furthermore, at least one natural form of potential dietary iodine is incompletely available to mice.
- Research Organization:
- Univ. of Tennessee Center for the Health Sciences, Memphis
- DOE Contract Number:
- AS05-76EV01643
- OSTI ID:
- 5655642
- Journal Information:
- Proc. Soc. Exp. Biol. Med.; (United States), Vol. 178:4
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
DIET
COMPARATIVE EVALUATIONS
IODINE
BIOLOGICAL AVAILABILITY
EXPERIMENTAL DATA
GOITER
METABOLISM
MICE
NUTRITIONAL DEFICIENCY
RATS
RESPONSE MODIFYING FACTORS
THYROID
ANIMALS
BODY
DATA
DISEASES
ELEMENTS
ENDOCRINE DISEASES
ENDOCRINE GLANDS
GLANDS
HALOGENS
INFORMATION
MAMMALS
NONMETALS
NUMERICAL DATA
ORGANS
RODENTS
VERTEBRATES
550500* - Metabolism