Modeling of exposure to carbon monoxide in fires

Journal Article · Sat Nov 01 00:00:00 EST 1980 · J. Combust. Toxicol.; (United States)

OSTI ID:5654930

Cagliostro, D E

A mathematical model is developed to predict carboxyhemoglobin concentrations in regions of the body for short exposures to carbon monoxide levels expected during escape from aircraft fires. The model includes the respiratory and circulatory dynamics of absorption and distribution of carbon monoxide and carboxyhemoglobin. Predictions of carboxyhemoglobin concentrations are compared to experimental values obtained for human exposures to constant high carbon monoxide levels. Predictions are within 20% of experimental values. For short exposure times, transient concentration effects are predicted. The effect of stress is studied and found to increase carboxyhemoglobin levels substantially compared to a rest state.

• Research Organization: NASA, Ames Research Center, Chemical Research Projects Office, Moffett Field, Calif.
• OSTI ID: 5654930
• Journal Information: J. Combust. Toxicol.; (United States), Vol. 7
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
BIOLOGICAL ACCUMULATION
MATHEMATICAL MODELS
CARBOXYHEMOGLOBIN
MAN
ACCIDENTS
AIR POLLUTION
AIRCRAFT
BLOOD CIRCULATION
CARBON MONOXIDE
COMBUSTION PRODUCTS
COMPOSITE MATERIALS
CONCENTRATION RATIO
FIRES
FORECASTING
POISONING
RESPIRATION
TESTING
TOXICITY
ANIMALS
CARBON COMPOUNDS
CARBON OXIDES
CHALCOGENIDES
MAMMALS
MATERIALS
OXIDES
OXYGEN COMPOUNDS
POLLUTION
PRIMATES
VERTEBRATES
551000* - Physiological Systems