Effects of prenatal /sup 60/Co irradiation on postnatal neural, learning, and hormonal development of the squirrel monkey

Journal Article · Mon Feb 01 00:00:00 EST 1982 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3575777· OSTI ID:5654290

Ordy, J M; Brizzee, K R; Dunlap, W P; Knight, C

The goals of this study were to examine the effects of 0, 50, and 100 rad of /sup 60/Co administered prenatally on postnatal development of neuromuscular coordination, visual discrimination learning, spontaneous light-dark stabilimeter activity, plasma cortisol, and somatometric growth rates of diurnal squirrel monkeys from birth to 90 days. In terms of accuracy, completeness, and time required for performance of reflexes and neuromuscular coordination, the performance of 50- and 100-rad offspring was less accurate and poorly coordinated and required more time for completion to that of controls. In visual orientation, discrimination, and reversal learning, the percentage correct responses of the 50- and 100-rad offspring were significantly lower than those of controls. Spontaneous light-dark stabilimeter activity of 50- and 100-rad offspring was significantly higher in the dark session than that of controls. Plasma cortisol was significantly higher in 100-rad infants than in controls. Comparisons of somatometric growth rates indicated that postnatal head circumference, crown-rump length, and to a lesser extent body weight increased at significantly slower rates in 50- and 100-rad offspring. These findings should provide essential information for formulating and carrying out multivariate behavioral, biochemical, and morphometric assessments of low-dose effects on the brain of primate offspring within demonstrable dose-response curves.

• Research Organization: Tulane Univ., Covington, Louisiana
• OSTI ID: 5654290
• Journal Information: Radiat. Res.; (United States), Vol. 89:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CENTRAL NERVOUS SYSTEM
BIOLOGICAL RADIATION EFFECTS
FETUSES
BEHAVIOR
COBALT 60
LOW DOSE IRRADIATION
MONKEYS
PREGNANCY
PRENATAL IRRADIATION
RADIATION DOSES
ANIMALS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
COBALT ISOTOPES
DOSES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IRRADIATION
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NUCLEI
ODD-ODD NUCLEI
PRENATAL EXPOSURE
PRIMATES
RADIATION EFFECTS
RADIOISOTOPES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals