Radiosensitization of Staphylococcus aureus by secobarbital sodium and other barbiturates
The barbiturate hypnotic, secobarbital sodium, at millimolar concentrations, sensitizes Staphylococcus aureus in anoxic buffer-saline suspension (pH 7.0) to the lethal effects of ..gamma.. rays. The maximal response represents 50% of that for oxygenated suspensions without additive. Secobarbital sodium operates within the oxygen effect. It must be present at the time of irradiation for modification of radiation response. This, coupled with its testing in the presence of other additives, points to its involvement in an intracellular reaction with a radiation-induced short-lived chemical species, probably the electron. Preliminary tests show that pentobarbital sodium also operates as an efficient hypoxic radiosensitizer. Lack of sensitization by phenobarbital sodium is attributed to its low lipid solubility.
- Research Organization:
- Hebrew Univ. of Jerusalem, Israel
- OSTI ID:
- 5653295
- Journal Information:
- Radiat. Res.; (United States), Vol. 96:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
BARBITURATES
PHARMACOLOGY
RADIOSENSITIVITY EFFECTS
CELL KILLING
RADIOINDUCTION
COBALT 60
GAMMA RADIATION
STAPHYLOCOCCUS
SURVIVAL CURVES
ANESTHETICS
AZINES
BACTERIA
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CENTRAL NERVOUS SYSTEM DEPRESSANTS
COBALT ISOTOPES
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYPNOTICS AND SEDATIVES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MICROORGANISMS
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
PYRIMIDINES
RADIATIONS
RADIOISOTOPES
YEARS LIVING RADIOISOTOPES
560131* - Radiation Effects on Microorganisms- Basic Studies- (-1987)
550700 - Microbiology