Carcinoma of the prostate irradiated by combined I/sup 125/ and external irradiation, analysis of failure and significance of positive biopsy one year or more after therapy

Journal Article · Tue Mar 01 00:00:00 EST 1983 · Int. J. Radiat. Oncol., Biol. Phys.; (United States)

DOI:https://doi.org/10.1016/0360-3016(83)90288-2· OSTI ID:5651910

Abadir, R; Ross, G Jr; Weinstein, S H

Sixty-three patients with cancer of the prostate T/sub 2/ or T/sub 3/ were evaluated. The protocol of treatment called for pelvic lymphadenectomy, 10,000 rad from I/sup 125/ implant and 4000 rad in 20 fractions using a Cobalt/sup 60/ machine. They were followed for 1 to 5 years with a plan to rebiopsy the prostate 1 to 2 years after therapy. Six of 59 evaluable patients (10%) showed progressive disease. Distinctive prognostic features in the failure group were younger age, larger prostate, more advanced stage, poorer differentiation, more possibility of positive pelvic lymph nodes, and if the nodes were positive, the involvement of more than two pelvic lymph nodes. On the other hand, the patients with controlled disease with or without positive prostatic biopsy on follow-up showed identical features regarding age, size of prostate, stage, differentiation, involvement of pelvic lymph nodes, and if the nodes were positive, only one or two nodes involved. Positive biopsy 1 to 2 years after radical irradiation in otherwise controlled disease is considered of no prognostic value.

• Research Organization: University of Missouri Health Sciences Center, Columbia
• OSTI ID: 5651910
• Journal Information: Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 9:3
• Country of Publication: United States
• Language: English

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