Radiation-induced taste aversion: effects of radiation exposure level and the exposure-taste interval
Radiation-induced taste aversion has been suggested to possibly play a role in the dietary difficulties observed in some radiotherapy patients. In rats, these aversions can still be formed even when the radiation exposure precedes the taste experience by several hours. This study was conducted to examine whether increasing the radiation exposure level could extend the range of the exposure-taste interval that would still support the formation of a taste aversion. Separate groups of rats received either a 100 or 300 R gamma-ray exposure followed 1, 3, 6, or 24 h later by a 10-min saccharin (0.1% w/v) presentation. A control group received a sham exposure followed 1 h later by a 10-min saccharin presentation. Twenty-four hours following the saccharin presentation all rats received a series of twelve 23-h two-bottle preference tests between saccharin and water. The results indicated that the duration of the exposure-taste interval plays an increasingly more important role in determining the initial extent of the aversion as the dose decreases. The course of recovery from taste aversion seems more affected by dose than by the temporal parameters of the conditioning trial.
- Research Organization:
- Florida State Univ., Tallahassee
- OSTI ID:
- 5650960
- Journal Information:
- Radiat. Res.; (United States), Vol. 2
- Country of Publication:
- United States
- Language:
- English
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RADIOTHERAPY
SIDE EFFECTS
TASTE BUDS
BIOLOGICAL RADIATION EFFECTS
DOSE-RESPONSE RELATIONSHIPS
GAMMA RADIATION
RADIATION DOSES
RATS
SACCHARIN
WATER
ANIMALS
AZOLES
BIOLOGICAL EFFECTS
BODY
DOSES
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
HYDROGEN COMPOUNDS
IONIZING RADIATIONS
MAMMALS
MEDICINE
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
ORGANS
OXYGEN COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RADIOLOGY
RODENTS
SENSE ORGANS
THERAPY
THIAZOLES
VERTEBRATES
560152* - Radiation Effects on Animals- Animals