Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies

Journal Article · Fri Jan 01 00:00:00 EST 1988 · AJR, Am. J. Roentgenol.; (United States)

DOI:https://doi.org/10.2214/ajr.150.1.189· OSTI ID:5650436

Di Chiro, G; Oldfield, E; Wright, D C; De Michele, D; Katz, D A; Patronas, N J; Doppman, J L; Larson, S M; Ito, M; Kufta, C V

Cerebral necrosis after radiotherapy for brain tumors is being recognized as a problem more common than previously estimated. Distinction between this iatrogenic complication and tumor recurrence cannot be made by either CT or MR imaging. By using positron emission tomography (PET) with /sup 18/F-deoxyglucose (FDG) we were able to reach a diagnosis of radiation necrosis, later verified, in 10 of 95 patients referred for the purpose of differentiating tumor recurrence from necrosis. The critical PET-FDG feature was focal hypometabolism in the area of necrosis, which contrasted with the hypermetabolism associated with the residual/recurrent tumor. In addition, four cases of cerebral necrosis after supraophthalmic, intraarterial chemotherapy (BCNU) were studied with the PET-FDG method. The area of chemotherapy damage was also characterized by marked hypometabolism. Histology revealed both similarities and differences between radio- and chemonecrosis.

• Research Organization: National Institute of Neurological and Communicative Disorders and Stroke, Bethesda, MD
• OSTI ID: 5650436
• Journal Information: AJR, Am. J. Roentgenol.; (United States), Vol. 150:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
62 RADIOLOGY AND NUCLEAR MEDICINE
BRAIN
NECROSIS
NEOPLASMS
POSITRON COMPUTED TOMOGRAPHY
CHEMOTHERAPY
SIDE EFFECTS
RADIOTHERAPY
BIOLOGICAL RADIATION EFFECTS
FLUORINE 18
GLUCOSE
PATIENTS
RADIATION INJURIES
ALDEHYDES
BETA DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
CARBOHYDRATES
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
FLUORINE ISOTOPES
HEXOSES
HOURS LIVING RADIOISOTOPES
INJURIES
ISOTOPES
LIGHT NUCLEI
MEDICINE
MONOSACCHARIDES
NERVOUS SYSTEM
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SACCHARIDES
THERAPY
TOMOGRAPHY
560151* - Radiation Effects on Animals- Man
550601 - Medicine- Unsealed Radionuclides in Diagnostics