Postirradiation administration of adenosine monophosphate combined with dipyridamole reduces early cellular damage in mice

Journal Article · Fri Jan 01 00:00:00 EST 1993 · Life Sciences; (United States)

DOI:https://doi.org/10.1016/0024-3205(93)90577-P· OSTI ID:5645430

Bohacek, J; Hosek, B; Pospisil, M ^[1]

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1. Academy of Sciences, Kralovopolska (Czech Republic)

The administration of dipyridamole and adenosine 5'-monophosphate (AMP) to mice 5 to 25 min after 1 Gy of total-body gamma irradiation was found to decrease cellular damage, as indicated by the thymidine level in plasma and the amount of saline soluble polynucleotides in the thymus. The drug combination used did not influence similar cytotoxic effects of hydrocortisone. Furthermore, it was shown that the addition of dipyridamole and AMP to in vitro irradiated suspensions of thymocytes enhanced the rejoining processes of DNA strand breaks. Receptor-mediated action of extracellular adenosine may be responsible for the therapeutic effects observed.

• OSTI ID: 5645430
• Journal Information: Life Sciences; (United States), Vol. 53:16; ISSN 0024-3205
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
GAMMA RADIATION
INHIBITION
AMP
DIPYRIDAMOLE
DNA REPAIR
MICE
STRAND BREAKS
THYMOCYTES
THYMUS
AMINES
ANIMALS
AZINES
BIOLOGICAL EFFECTS
BIOLOGICAL RECOVERY
BIOLOGICAL REPAIR
BODY
CARDIOVASCULAR AGENTS
DRUGS
ELECTROMAGNETIC RADIATION
HETEROCYCLIC COMPOUNDS
IONIZING RADIATIONS
LYMPHATIC SYSTEM
MAMMALS
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIPERIDINES
PYRIDINES
RADIATION EFFECTS
RADIATIONS
REPAIR
RODENTS
SOMATIC CELLS
VASODILATORS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals
560120 - Radiation Effects on Biochemicals
Cells
& Tissue Culture