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Title: Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract

Abstract

Factors affecting liposome transport to the blood compartment after oral administration to rats were evaluated. A high entrapment of calcitonin (CT) was obtained when the vesicles were prepared by sonication and were composed of egg phosphatidylcholine, cholesterol and stearylamine. In vitro tests showed that the liposomes were stable in light acidic or basic buffers, but that they were partly lysed in pH 2.5, 10 mM bile salts and pancreatin. Oral administration of liposomes entrapping calcitonin in fasting rats showed that the vesicles facilitate transport of the hormone to the general circulation and that they increase the lifetime of [sup 125]I-CT in blood. Oral administration of liposomes entrapping radioactive indium in fasting rats did not induce radioactivity in blood. This could be explained by disruption of most of the vesicles in the enterocytes.

Authors:
; ; ;  [1]
  1. Universite de Bordeaux II (France)
Publication Date:
OSTI Identifier:
5645429
Resource Type:
Journal Article
Journal Name:
Life Sciences; (United States)
Additional Journal Information:
Journal Volume: 53:16; Journal ID: ISSN 0024-3205
Country of Publication:
United States
Language:
English
Subject:
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.; INDIUM; ENCAPSULATION; RADIONUCLIDE KINETICS; LIPOSOMES; ORAL ADMINISTRATION; STABILITY; CALCITONIN; GASTROINTESTINAL TRACT; IN VITRO; IN VIVO; DIGESTIVE SYSTEM; ELEMENTS; HORMONES; METALS; ORGANIC COMPOUNDS; PEPTIDE HORMONES; PEPTIDES; POLYPEPTIDES; PROTEINS; 560160* - Radionuclide Effects, Kinetics, & Toxicology

Citation Formats

Arieen, A, Goigoux, C, Baquey, C, and Dupuy, B. Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract. United States: N. p., 1993. Web. doi:10.1016/0024-3205(93)90573-L.
Arieen, A, Goigoux, C, Baquey, C, & Dupuy, B. Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract. United States. https://doi.org/10.1016/0024-3205(93)90573-L
Arieen, A, Goigoux, C, Baquey, C, and Dupuy, B. 1993. "Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract". United States. https://doi.org/10.1016/0024-3205(93)90573-L.
@article{osti_5645429,
title = {Study of in vitro and in vivo stability of liposomes loaded with calcitonin or indium in the gastrointestinal tract},
author = {Arieen, A and Goigoux, C and Baquey, C and Dupuy, B},
abstractNote = {Factors affecting liposome transport to the blood compartment after oral administration to rats were evaluated. A high entrapment of calcitonin (CT) was obtained when the vesicles were prepared by sonication and were composed of egg phosphatidylcholine, cholesterol and stearylamine. In vitro tests showed that the liposomes were stable in light acidic or basic buffers, but that they were partly lysed in pH 2.5, 10 mM bile salts and pancreatin. Oral administration of liposomes entrapping calcitonin in fasting rats showed that the vesicles facilitate transport of the hormone to the general circulation and that they increase the lifetime of [sup 125]I-CT in blood. Oral administration of liposomes entrapping radioactive indium in fasting rats did not induce radioactivity in blood. This could be explained by disruption of most of the vesicles in the enterocytes.},
doi = {10.1016/0024-3205(93)90573-L},
url = {https://www.osti.gov/biblio/5645429}, journal = {Life Sciences; (United States)},
issn = {0024-3205},
number = ,
volume = 53:16,
place = {United States},
year = {Fri Jan 01 00:00:00 EST 1993},
month = {Fri Jan 01 00:00:00 EST 1993}
}