Temporal alignment of tissue and arterial data and selection of integration start times for the H[sub 2] [sup 15]O autoradiographic CBF model in PET

Journal Article · Wed Sep 01 00:00:00 EDT 1993 · IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States)

DOI:https://doi.org/10.1109/42.241866· OSTI ID:5641368

Muzic, Jr, R F ^[1]; Nelson, A D; Miraldi, F ^[2]

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1. Case Western Reserve Univ., Cleveland, OH (United States). Dept. of Biomedical Engineering
2. Univ. Hospitals of Cleveland, OH (United States). Div. of Nuclear Medicine

A technique has been developed and tested that provides an automated method of temporally aligning the PET tissue activity curve with the arterial activity curve for quantification of cerebral blood flow using the H[sub 2] [sup 15]O autoradiographic model. This technique not only determines the relative time delay between the two curves, but also provides the start time of integration. Variability in computing global cerebral blood flow using this technique is shown to be less than that obtained by trained observers manually selecting parameters and at least as good as that obtained by using another automated alignment technique.

• OSTI ID: 5641368
• Journal Information: IEEE Transactions on Medical Imaging (Institute of Electrical and Electronics Engineers); (United States), Vol. 12:3; ISSN 0278-0062
• Country of Publication: United States
• Language: English

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AUTORADIOGRAPHY
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