Radioisotopes for radioimmunodetection (RAID) and radioimmunotherapy (RAIT)---current and new perspectives
In this paper the availability and properties of radioisotopes for both radioimmunodiagnosis (RAID) and radioimmunotherapy (RAIT) are discussed. Examples are provided for radioisotopes available via direct production in nuclear reactors and accelerators or as daughters obtained from radionuclide generator systems whose parents are either reactor or accelerator produced. Important factors which must be considered for the use of a particular radioisotope include availability, the physical half-life and decay properties, and chemical versatility for protein attachment. Although both direct'' and indirect'' methods are available for attachment of radioisotopes to antibodies, this broad field of research is not reviewed in detail. Practical issues related to the availability and use of a variety of radionuclides are described. 47 refs., 5 tabs.
- Research Organization:
- Oak Ridge National Lab., TN (United States)
- Sponsoring Organization:
- USDOE; USDOE, Washington, DC (United States)
- DOE Contract Number:
- AC05-84OR21400
- OSTI ID:
- 5641118
- Report Number(s):
- CONF-9110147-1; ON: DE91014107
- Resource Relation:
- Conference: Society of Nuclear Medicine southeastern chapter meeting, Hollywood, FL (United States), 11-13 Oct 1991
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
ISOTOPE PRODUCTION
REVIEWS
NEOPLASMS
RADIOIMMUNODETECTION
RADIOIMMUNOTHERAPY
ACCELERATORS
ANTIBODIES
ASTATINE 211
BIOLOGICAL LOCALIZATION
CHEMICAL REACTIONS
COPPER 67
DAUGHTER PRODUCTS
DECAY
GOLD 199
HALF-LIFE
HOLMIUM 166
INDIUM 111
IODINATION
IODINE 125
IODINE 131
IRIDIUM 194
ISOTOPE PRODUCTION REACTORS
LABELLING
LEAD 203
LET
MAN
NUCLEAR MEDICINE
POSITRON COMPUTED TOMOGRAPHY
RADIOISOTOPE GENERATORS
RADIOISOTOPES
RADIONUCLIDE KINETICS
RADIOPHARMACEUTICALS
RHENIUM 186
RHENIUM 188
SEPARATION PROCESSES
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
TECHNETIUM 99
YTTRIUM 90
ALPHA DECAY RADIOISOTOPES
ANIMALS
ASTATINE ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
COMPUTERIZED TOMOGRAPHY
COPPER ISOTOPES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
DOCUMENT TYPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ENERGY TRANSFER
EVEN-ODD NUCLEI
GOLD ISOTOPES
HALOGENATION
HEAVY NUCLEI
HOLMIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
IMMUNOLOGY
IMMUNOTHERAPY
INDIUM ISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IODINE ISOTOPES
IRIDIUM ISOTOPES
IRRADIATION REACTORS
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
LABELLED COMPOUNDS
LEAD ISOTOPES
MAMMALS
MEDICINE
MINUTES LIVING RADIOISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
PRIMATES
RADIOIMMUNOLOGY
RADIOLOGY
RADIOTHERAPY
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
REACTORS
RHENIUM ISOTOPES
SECONDS LIVING RADIO
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THERAPY
TOMOGRAPHY
TRACER TECHNIQUES
VERTEBRATES
YEARS LIVING RADIOI
YEARS LIVING RADIOISOTOPES
YTTRIUM ISOTOPES
400703* - Radiochemistry & Nuclear Chemistry- Radioisotope Production
550604 - Medicine- Unsealed Radionuclides in Therapy- (1980-)
550601 - Medicine- Unsealed Radionuclides in Diagnostics