Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation

Oris, J T

doi:10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2

Title: Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation

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Abstract

The purpose of this study was to describe statistical procedures to test the equivalence of concentration-response relationships in acute toxicology studies and to illustrate the implications of nonequivalence on potency endpoints such as LC10, LC50, or LC90. A logistic regression model for binary response endpoints such as mortality that allowed for the examination of equivalence of slopes and intercepts of the responses between populations is described. Test statistics were derived from comparing nested regression models. This procedure was used to test the equivalence of concentration versus acute mortality response relationships between two nonpolar, narcotic chemicals in a single population of fish and between two populations of fish with different exposure histories to a polycyclic aromatic hydrocarbon. These case studies illustrate different outcomes in the comparison of concentration-response relationships and demonstrate the need to consider more than a single endpoint (e.g., LC50) in a risk assessment context when nonparallel concentration-responses are observed.

Authors:

Oris, J T ^[1]

Miami Univ., Oxford, OH (United States). Center for Environmental Toxicology and Statistics

Publication Date:: Wed Oct 01 00:00:00 EDT 1997

Sponsoring Org.:: USDOE

OSTI Identifier:: 564003

Resource Type:: Journal Article

Journal Name:: Environmental Toxicology and Chemistry

Additional Journal Information:: Journal Volume: 16; Journal Issue: 10; Other Information: PBD: Oct 1997

Country of Publication:: United States

Language:: English

Subject:: 54 ENVIRONMENTAL SCIENCES; 56 BIOLOGY AND MEDICINE, APPLIED STUDIES; WATER POLLUTION; BIOLOGICAL INDICATORS; POLYCYCLIC AROMATIC HYDROCARBONS; DOSE-RESPONSE RELATIONSHIPS; BIOASSAY; MATHEMATICAL MODELS

Citation Formats


                    Oris, J T. Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation.  United States: N. p., 1997. 
        Web.  doi:10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2.

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                    Oris, J T. Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation.  United States.  https://doi.org/10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2

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                    Oris, J T. 1997.  
        "Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation".  United States.  https://doi.org/10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2.

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@article{osti_564003,

  title        = {Equivalence of concentration-response relationships in aquatic toxicology studies: Testing and implications for potency estimation},

  author       = {Oris, J T},

  abstractNote = {The purpose of this study was to describe statistical procedures to test the equivalence of concentration-response relationships in acute toxicology studies and to illustrate the implications of nonequivalence on potency endpoints such as LC10, LC50, or LC90. A logistic regression model for binary response endpoints such as mortality that allowed for the examination of equivalence of slopes and intercepts of the responses between populations is described. Test statistics were derived from comparing nested regression models. This procedure was used to test the equivalence of concentration versus acute mortality response relationships between two nonpolar, narcotic chemicals in a single population of fish and between two populations of fish with different exposure histories to a polycyclic aromatic hydrocarbon. These case studies illustrate different outcomes in the comparison of concentration-response relationships and demonstrate the need to consider more than a single endpoint (e.g., LC50) in a risk assessment context when nonparallel concentration-responses are observed.},

  doi          = {10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2},

  url          = {https://www.osti.gov/biblio/564003},
  journal      = {Environmental Toxicology and Chemistry},
number       = 10,

  volume       = 16,

  place        = {United States},

  year         = {Wed Oct 01 00:00:00 EDT 1997},

  month        = {Wed Oct 01 00:00:00 EDT 1997}

}

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https://doi.org/10.1897/1551-5028(1997)016<2204:EOCRRI>2.3.CO;2

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