Iodine-125-labeled triiodothyronine in rat brain: evidence for localization in discrete neural systems

Journal Article · Fri Jan 15 00:00:00 EST 1982 · Science (Washington, D.C.); (United States)

DOI:https://doi.org/10.1126/science.7053582· OSTI ID:5639714

Dratman, M B ^[1]; Futaesaku, Y; Crutchfield, F L; Berman, N; Payne, B; Sar, M; Stumpf, W E

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1. Philadelphia Veterans Administration Hospital, PA

Autoradiograms prepared from adult rat brains demonstrate that nerve cells and neuropil in different brain regions selectively concentrate and retain intravenously administered triiodothyronine, by mechanisms susceptible to saturation with excess triiodothyronine. A neuroregulatory role for thyroid hormones, strongly supported by the observations, may account for their marked effects on behavior and the activity of the autonomic nervous system.

• OSTI ID: 5639714
• Journal Information: Science (Washington, D.C.); (United States), Vol. 215
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
IODINE 125
ISOTOPE APPLICATIONS
NERVE CELLS
BIOCHEMISTRY
TRIIODOTHYRONINE
METABOLISM
BIOLOGICAL LOCALIZATION
BRAIN
LABELLED COMPOUNDS
PHYSIOLOGY
RATS
SENSITIVITY
ANIMAL CELLS
ANIMALS
BETA DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
CHEMISTRY
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
MAMMALS
NERVOUS SYSTEM
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
RODENTS
SOMATIC CELLS
THYROID HORMONES
VERTEBRATES
550201* - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques