Singlet oxygen production from the reactions of ozone with biological molecules

Journal Article · Wed May 15 00:00:00 EDT 1991 · Journal of Biological Chemistry; (USA)

OSTI ID:5639691

Kanofsky, J R; Sima, P ^[1]

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1. Department of Veterans Affairs Hospital, Hines, IL (USA)

The reaction of ozone with a number of biological molecules was found to produce singlet oxygen in high yield. At pH 7.0, the reaction of ozone with an equimolar amount of biological molecule produced the following singlet oxygen yields (mole of singlet oxygen/mole of ozone): cysteine, 0.49 +/- 0.02; methionine, 1.13 +/- 0.11; reduced glutathione, 0.33 +/- 0.02; albumin, 1.00 +/- 0.05; uric acid, 0.64 +/- 0.09; ascorbic acid, 0.96 +/- 0.007; NADPH, 1.07 +/- 0.07; NADH, 0.95 +/- 0.01. Thus, singlet oxygen may be an important intermediate in the biochemical damage caused by ozone.

• OSTI ID: 5639691
• Journal Information: Journal of Biological Chemistry; (USA), Vol. 266:14; ISSN 0021-9258
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
OZONE
TOXICITY
RADICALS
BIOSYNTHESIS
ALBUMINS
ANTIOXIDANTS
ASCORBIC ACID
CYSTEINE
GLUTATHIONE
HISTIDINE
LUMINESCENCE
METHIONINE
NADH2
NADP
SOLVENTS
URIC ACID
AMINO ACIDS
AROMATICS
AZAARENES
AZOLES
CARBOXYLIC ACIDS
COENZYMES
DRUGS
HETEROCYCLIC ACIDS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
LIPOTROPIC FACTORS
NUCLEOTIDES
ORGANIC ACIDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANIC OXYGEN COMPOUNDS
ORGANIC SULFUR COMPOUNDS
PEPTIDES
POLYPEPTIDES
PROTEINS
PURINES
RADIOPROTECTIVE SUBSTANCES
SYNTHESIS
THIOLS
VITAMINS
XANTHINES
560300* - Chemicals Metabolism & Toxicology