Tissue localization of stable and radioactive nuclides by secondary-ion microscopy
Images of the distribution of a given nuclide in a section of biological tissue can be obtained at the microscopic level by ''secondary-ion mass analysis.'' In this method, the images are formed by an ion-emission microscope wherein the specimen's atoms are progressively sputtered from the surface and the ions are selectively visualied by mass spectrometry according to their mass-to-charge ratios. Such images are obtained at the cost of the destruction of the specimen, which is progressively eroded at the rate of 1-10 atomic layers per second. The spatial resolution is better than 1 ..mu..m for an imaged area 250 ..mu..m in diameter and a section thickness of 1-2000 nm;thus, the analytical images are element distributions representaive of 3-6000 atomic layers. Distributional images can be obtained for many nuclides, whether stable or radioactive, natural or artifically administered.
- Research Organization:
- Faculte de Medecine, Creteil, France
- OSTI ID:
- 5639192
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 23:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ION EMISSION
DIAGNOSTIC USES
MICROSCOPY
RADIOISOTOPES
BIOLOGICAL LOCALIZATION
TISSUES
DIAGNOSIS
EVALUATION
IMAGES
MASS SPECTROSCOPY
BODY
ISOTOPES
SPECTROSCOPY
USES
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