Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid

Skowsky, W R; Wilf, L H

Title: Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid

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Abstract

We have presented a case of sporadic medullary carcinoma of the thyroid with documentation of localization of tracer {sup 131}I-MIBG within the primary neoplasm. A review of the nuclear medicine literature of localization techniques for MCT demonstrates that {sup 131}I-MIBG, while an excellent choice for diagnosis of pheochromocytoma and neuroblastoma, produces low yield and unpredictable concentration in other neural crest apudomas, including MCT. A low incidence of true-positive results with {sup 131}I-MIBG uptake and a high incidence of false-negative results make this radiopharmaceutical a suboptimal choice for diagnostic studies, but a potentially promising one as a therapeutic agent.33 references.

Authors:

Skowsky, W R; Wilf, L H ^[1]

Univ. of Florida School of Medicine, Jacksonville (USA)

Publication Date:: Wed May 01 00:00:00 EDT 1991

OSTI Identifier:: 5638808

Resource Type:: Journal Article

Journal Name:: Southern Medical Journal; (USA)

Additional Journal Information:: Journal Volume: 84:5; Journal ID: ISSN 0038-4348

Country of Publication:: United States

Language:: English

Subject:: 62 RADIOLOGY AND NUCLEAR MEDICINE; CARCINOMAS; DIAGNOSIS; IODINE 131; UPTAKE; THYROID; PATIENTS; SCINTISCANNING; BETA DECAY RADIOISOTOPES; BETA-MINUS DECAY RADIOISOTOPES; BODY; COUNTING TECHNIQUES; DAYS LIVING RADIOISOTOPES; DIAGNOSTIC TECHNIQUES; DISEASES; ENDOCRINE GLANDS; GLANDS; INTERMEDIATE MASS NUCLEI; IODINE ISOTOPES; ISOTOPES; NEOPLASMS; NUCLEI; ODD-EVEN NUCLEI; ORGANS; RADIOISOTOPE SCANNING; RADIOISOTOPES; 550601* - Medicine- Unsealed Radionuclides in Diagnostics

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                    Skowsky, W R, and Wilf, L H. Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid.  United States: N. p., 1991. 
        Web.

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                    Skowsky, W R, & Wilf, L H. Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid.  United States.

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                    Skowsky, W R, and Wilf, L H. 1991.  
        "Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid".  United States.

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@article{osti_5638808,

  title        = {Iodine 131 metaiodobenzylguanidine scintigraphy of medullary carcinoma of the thyroid},

  author       = {Skowsky, W R and Wilf, L H},

  abstractNote = {We have presented a case of sporadic medullary carcinoma of the thyroid with documentation of localization of tracer {sup 131}I-MIBG within the primary neoplasm. A review of the nuclear medicine literature of localization techniques for MCT demonstrates that {sup 131}I-MIBG, while an excellent choice for diagnosis of pheochromocytoma and neuroblastoma, produces low yield and unpredictable concentration in other neural crest apudomas, including MCT. A low incidence of true-positive results with {sup 131}I-MIBG uptake and a high incidence of false-negative results make this radiopharmaceutical a suboptimal choice for diagnostic studies, but a potentially promising one as a therapeutic agent.33 references.},

  doi          = {},

  url          = {https://www.osti.gov/biblio/5638808},
  journal      = {Southern Medical Journal; (USA)},

  issn         = {0038-4348},

  number       = ,

  volume       = 84:5,

  place        = {United States},

  year         = {Wed May 01 00:00:00 EDT 1991},

  month        = {Wed May 01 00:00:00 EDT 1991}

}

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